Davis K P, Hartmann L K, Keeney G L, Shapiro H
Department of Gynecologic Oncology, Presbyterian St. Lukes Medical Center, Colorado 80218,USA.
Gynecol Oncol. 1996 May;61(2):259-65. doi: 10.1006/gyno.1996.0136.
Primary ovarian carcinoid tumors were reviewed from Mayo Clinic and Colorado Tumor Registry data. A total of 17 patients with this diagnosis were identified. Histologic analysis of these carcinoid tumors revealed 9 (53%) were insular, 5 (29%) were trabecular, and 4 (26%) were strumal carcinoid with or without a mature dermoid component. There were 11 patients with stage I and 6 patients with stage III or IV disease at diagnosis. Carcinoid syndrome was found in 29% of patients. Pressure or pain with defecation was noted in 41% of cases. Recurrence of tumor occurred in 1 of 11 patients with suspected stage I disease 13 years after initial diagnosis. Overall survival was excellent in the 11 patients whose disease was confined to one ovary (100% 5-year survival), but only 1 of 6 patients survived (33% 5-year survival) if advanced stage at diagnosis. Systemic chemotherapy for advanced disease achieved a complete response in 1 patient and stable disease in another. Although rare, primary ovarian carcinoid tumors treated with surgery alone and found to be confined to the ovary can be expected to have an excellent overall outcome.
我们回顾了梅奥诊所和科罗拉多肿瘤登记处数据中的原发性卵巢类癌肿瘤。共识别出17例患有该疾病的患者。对这些类癌肿瘤的组织学分析显示，9例（53%）为岛状，5例（29%）为小梁状，4例（26%）为甲状腺肿类癌，伴有或不伴有成熟的皮样成分。诊断时，11例患者为I期，6例患者为III期或IV期疾病。29%的患者出现类癌综合征。41%的病例在排便时出现压迫感或疼痛。11例疑似I期疾病的患者中有1例在初次诊断13年后出现肿瘤复发。疾病局限于一侧卵巢的11例患者总体生存率良好（5年生存率100%），但如果诊断时处于晚期，6例患者中只有1例存活（5年生存率33%）。晚期疾病的全身化疗使1例患者达到完全缓解，另1例患者病情稳定。虽然罕见，但仅接受手术治疗且局限于卵巢的原发性卵巢类癌肿瘤预计总体预后良好。
