Markum Eric, Baillie John
Center for Biomedical Research, Boise, ID, USA.
J Drugs Dermatol. 2012 Mar;11(3):349-54.
Molluscum contagiosum is a common childhood viral skin condition and is increasingly found as a sexually transmitted disease in adults. Current treatment options are invasive, requiring tissue destruction and attendant discomfort. Fifty-three children (mean age 6.3+5.1 years) with the diagnosis of molluscum contagiosum were treated with twice daily topical application of either essential oil of Melaleuca alternifolia (TTO), a combination of TTO and organically bound iodine (TTO-I), or iodine alone. At the end of 30 days, 48 children were available for follow up. A greater than 90% reduction in the number of lesions was observed in 16 of 19 children treated with TTO-I, while 1 of 16 and 3 of 18 children met the same criteria for improvement in the iodine and TTO groups (P<0.01, ANOVA) respectively by intention-to-treat analysis. No child discontinued treatment due to adverse events. The combination of essential oil of M. alternifolia with organically bound iodine offers a safe therapeutic alternative in the treatment of childhood molluscum. Clinical Trial Registry ACTRN12610000984099.
传染性软疣是一种常见的儿童病毒性皮肤病，在成人中作为性传播疾病也越来越多地被发现。目前的治疗方法具有侵入性，需要组织破坏并伴有不适。53名被诊断为传染性软疣的儿童（平均年龄6.3±5.1岁）接受了每日两次的局部治疗，分别使用互叶白千层精油（TTO）、TTO与有机结合碘的组合（TTO-I）或仅使用碘。30天结束时，48名儿童可供随访。在意向性分析中，接受TTO-I治疗的19名儿童中有16名病变数量减少了90%以上，而碘组的16名儿童中有1名、TTO组的18名儿童中有3名达到了相同的改善标准（方差分析，P<0.01）。没有儿童因不良事件而停止治疗。互叶白千层精油与有机结合碘的组合为儿童传染性软疣的治疗提供了一种安全的治疗选择。临床试验注册编号：ACTRN12610000984099。
