多重散射光层析成像与共聚焦成像：检测年龄相关性黄斑变性中的新生血管形成

Multiply scattered light tomography and confocal imaging: detecting neovascularization in age-related macular degeneration.

作者信息

Elsner A, Miura M, Burns S, Beausencourt E, Kunze C, Kelley L, Walker J, Wing G, Raskauskas P, Fletcher D, Zhou Q, Dreher A

出版信息

Opt Express. 2000 Jul 17;7(2):95-106. doi: 10.1364/oe.7.000095.

DOI:10.1364/oe.7.000095

PMID:19404374

Abstract

A novel technique, Multiply Scattered Light Tomography (MSLT), and confocal Infrared Imaging are used to provide diagnostic information using a comfortable, rapid, and noninvasive method. We investigated these techniques in detecting neovascularization in age-related macular degeneration. The MSLT used a Vertical Cavity Surface Emitting Laser (VCSEL) at 850 nm, while the confocal imaging technique used either the VCSEL or a 790 nm laser diode. Both were implemented into the topographical scanning system (TopSS, Laser Diagnostic Technologies, Inc.) Confocal imaging with both lasers provided different information about neovascularization as a function of focal plane, and different also from MSLT.

摘要

一种新技术——多重散射光断层扫描（MSLT）以及共焦红外成像，被用于通过一种舒适、快速且无创的方法来提供诊断信息。我们研究了这些技术在检测年龄相关性黄斑变性中的新生血管形成情况。MSLT使用一个850纳米的垂直腔面发射激光器（VCSEL），而共焦成像技术使用VCSEL或一个790纳米的激光二极管。两者都被应用于地形扫描系统（TopSS，激光诊断技术公司）。两种激光器的共焦成像提供了关于新生血管形成的与焦平面相关的不同信息，并且也与MSLT提供的信息不同。