Elsner A E, Zhou Q, Beck F, Tornambe P E, Burns S A, Weiter J J, Dreher A W
Schepens Eye Research Institute, San Diego, USA.
Int Ophthalmol. 2001;23(4-6):245-50. doi: 10.1023/a:1014405320509.
to use a novel technique, Multiply Scattered Light Tomography (MSLT), to provide a comfortable, rapid, and noninvasive method for detection and management of Age-related Macualar Degeneration.
two patient groups were studied in clinical settings with MSLT and confocal scanning laser tomography. In Poway, CA, 21 retinal patients underwent tomography, and the 17 patients with suspicion of exudation also had ICG. An Angio-Scan (Laser Diagnostic Technologies, Inc.) was used to provide simultaneous fundus reflectance and ICG imaging. In Methuen, MA, 20 retinal patients underwent tomography with fluorescein angiography for suspicion of exudation. The MSLT was based on the TopSS (Laser Diagnostic Technologies, Inc.), with a Vertical Cavity Surface Emitting Laser array at 850 mm as the illumination source. The central laser produced confocal images. The surrounding lasers produced multiply scattered light images.
MSLT emphasized structures beneath the retina such as drusen, choroidal new vessel membranes, and pigment epithelial detachments. Exudation seen on angiography was visualized by MSLT as topographical structures with distinct borders. Superficial structures, e.g., cysts and epiretinal membranes, were visualized in 850 nm images.
confocal tomography and MSLT provided a rapid, noninvasive method to detect and localize macular degeneration and pathological structures found in eyes of older patients.
使用一种新技术——多重散射光断层扫描（MSLT），提供一种用于检测和管理年龄相关性黄斑变性的舒适、快速且无创的方法。
在临床环境中，对两组患者进行了MSLT和共焦扫描激光断层扫描研究。在加利福尼亚州波威市，21名视网膜患者接受了断层扫描，17名疑似有渗出的患者还进行了吲哚青绿血管造影（ICG）。使用血管扫描设备（激光诊断技术公司）同时提供眼底反射率和ICG成像。在马萨诸塞州梅休因市，20名视网膜患者因疑似渗出接受了荧光素血管造影断层扫描。MSLT基于TopSS（激光诊断技术公司），以850毫米处的垂直腔面发射激光器阵列作为照明源。中央激光器产生共焦图像。周围的激光器产生多重散射光图像。
MSLT突出了视网膜下方的结构，如玻璃膜疣、脉络膜新生血管膜和色素上皮脱离。血管造影中看到的渗出在MSLT中显示为边界清晰的地形结构。850纳米图像中可见浅表结构，如囊肿和视网膜前膜。
共焦断层扫描和MSLT提供了一种快速、无创的方法来检测和定位老年患者眼中的黄斑变性和病理结构。
