von Ehrenstein Ondine S, Fenton Suzanne E, Kato Kayoko, Kuklenyik Zsuzsanna, Calafat Antonia M, Hines Erin P
UCLA School of Public Health, University of California, Los Angeles, CA, United States.
US Environmental Protection Agency, ORD, NHEERL, Reproductive Toxicology Division, RTP, NC, United States.
Reprod Toxicol. 2009 Jun;27(3-4):239-245. doi: 10.1016/j.reprotox.2009.03.001. Epub 2009 Mar 6.
Polyfluoroalkyl chemicals (PFCs) comprise a group of man-made organic compounds, some of which are persistent contaminants with developmental toxicity shown in laboratory animals. There is a paucity of human perinatal exposure data. The US EPA conducted a pilot study (Methods Advancement for Milk Analysis) including 34 breastfeeding women in North Carolina. Milk and serum samples were collected at 2-7 weeks and 3-4 months postpartum; 9 PFCs were assessed in milk and 7 in serum. Perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorohexane sulfonic acid (PFHxS) were found in nearly 100% of the serum samples. PFOS and PFOA were found at the highest concentrations. PFCs were below the limit of quantification in most milk samples. Serum concentrations of PFOS, PFOA and PFHxS were lower (p<0.01) at the second visit compared to the first visit. Living in North Carolina 10 years or longer was related to elevated PFOS, PFOA and PFNA (p<or=0.03). These pilot data support the need to further explore perinatal PFC exposures and potentially related health effects, as planned in the upcoming National Children's Study which provided the framework for this investigation.
多氟烷基化合物（PFCs）是一类人造有机化合物，其中一些是持久性污染物，在实验动物中显示出发育毒性。目前人类围产期暴露数据匮乏。美国环境保护局开展了一项试点研究（牛奶分析方法改进研究），纳入了北卡罗来纳州的34名哺乳期妇女。在产后2至7周以及3至4个月时采集了乳汁和血清样本；对乳汁中的9种全氟化合物和血清中的7种进行了评估。在几乎100%的血清样本中都检测到了全氟辛烷磺酸（PFOS）、全氟辛酸（PFOA）、全氟壬酸（PFNA）和全氟己烷磺酸（PFHxS）。PFOS和PFOA的浓度最高。大多数乳汁样本中的全氟化合物低于定量限。与首次访视相比，第二次访视时血清中PFOS、PFOA和PFHxS的浓度较低（p<0.01）。在北卡罗来纳州居住10年或更长时间与PFOS、PFOA和PFNA水平升高有关（p≤0.03）。这些试点数据支持有必要进一步探索围产期全氟化合物暴露情况以及潜在的相关健康影响，正如即将开展的国家儿童研究计划的那样，该研究为此项调查提供了框架。
