Wang Kung-Liahng, Wang Tao-Yeuan, Huang Yu-Chuen, Lai Jerry Cheng-Yen, Chang Ting-Chang, Yen Ming-Shyen
Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taiwan.
J Formos Med Assoc. 2009 May;108(5):428-32. doi: 10.1016/S0929-6646(09)60088-7.
Large-cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a very rare malignancy. We aimed to investigate the role of human papillomavirus (HPV) on the survival of patients, and its correlation with clinical parameters of HPV status or survival outcomes. Only seven cases of LCNEC were retrospectively collected among 8018 (0.087%) invasive cervical carcinomas from the cancer registry systems at Mackay Memorial Hospital and Veterans General Hospital over a period of 17 years. The median survival time was 17.2 months, including only one long-term survivor (> 5 years). The 2 year and 5-year survival rates after diagnosis were 42% and 30%, respectively. The results indicated that the majority of LCNEC cases were dominated by high-risk HPV-18. No clinical parameters appeared to be associated with HPV-18 or survival outcomes of LCNEC patients. Pelvic lymph node metastasis positivity could also be considered as a prognostic factor for this disease.
子宫颈大细胞神经内分泌癌（LCNEC）是一种非常罕见的恶性肿瘤。我们旨在研究人乳头瘤病毒（HPV）在患者生存中的作用，及其与HPV状态或生存结果的临床参数之间的相关性。在17年的时间里，从马偕纪念医院和荣民总医院的癌症登记系统中回顾性收集的8018例浸润性宫颈癌中，仅发现7例LCNEC（0.087%）。中位生存时间为17.2个月，其中只有1例长期存活者（>5年）。诊断后的2年和5年生存率分别为42%和30%。结果表明，大多数LCNEC病例以高危HPV-18为主。没有临床参数似乎与LCNEC患者的HPV-18或生存结果相关。盆腔淋巴结转移阳性也可被视为该疾病的一个预后因素。
