人类围产期巨细胞病毒感染
Perinatal cytomegalovirus infection in man.
作者信息
Granström M, Leinikki P, Santavuori P, Pettay O
出版信息
Arch Dis Child. 1977 May;52(5):354-9. doi: 10.1136/adc.52.5.354.
In a prospective study of 148 children from urbanized southern Finland 3 were found to be congenitally and 48 perinatally infected with cytomegalovirus (CMV), while 6 developed "late" infection during the first year of life. During pregnancy and the first year after delivery 23 of the mothers had no CMV antibodies; none of the children of these seronegative mothers developed any type of CMV infection. Fresh blood exchange transfusions did not increase the risk of CMV infection. The data support the hypothesis that the mother is the source of perinatal CMV infection. Children with a low birthweight not due to prematurity, and first children seem to run a greater risk of acquiring perinatal CMV infection. If the child is breast fed up to the age of 2 months the risk seems to be increased. Perinatal CMV infection gave rise to no symptoms or signs and had no effect on growth or on motor and psychosocial development during the first year of life.
在一项对芬兰南部城市化地区148名儿童的前瞻性研究中，发现3名儿童先天性感染巨细胞病毒（CMV），48名儿童围产期感染CMV，另有6名儿童在出生后第一年内发生“迟发性”感染。在孕期及产后第一年，23名母亲无CMV抗体；这些血清学阴性母亲的孩子均未发生任何类型的CMV感染。新鲜血液交换输血并未增加CMV感染风险。这些数据支持母亲是围产期CMV感染源这一假说。非早产的低体重儿及头胎儿童似乎发生围产期CMV感染的风险更高。如果儿童母乳喂养至2个月大，感染风险似乎会增加。围产期CMV感染未引起任何症状或体征，对出生后第一年内的生长、运动及心理社会发育也无影响。
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