米罗-米尔顿复合体对线粒体动力学的钙离子依赖性调控。
Ca2+-dependent regulation of mitochondrial dynamics by the Miro-Milton complex.
作者信息
Liu Xingguo, Hajnóczky György
机构信息
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
出版信息
Int J Biochem Cell Biol. 2009 Oct;41(10):1972-6. doi: 10.1016/j.biocel.2009.05.013. Epub 2009 May 27.
Abstract
Calcium oscillations control mitochondrial motility along the microtubules and in turn, support on-demand distribution of mitochondria. However, the mechanism mediating the Ca(2+) effect remained a mystery. Recently, several papers reported on the Ca(2+)-dependent regulation of mitochondrial dynamics by a Miro-Milton complex linking mitochondria to kinesin motors. Both mitochondrial motility and fusion-fission dynamics seem to be sensitive to a Ca(2+)-dependent switch by this complex. Evidence is emerging that calcium signaling through Miro-Milton is central to coordination of the local oxidative metabolism with the energy demands and protection against Ca(2+)-induced cell injury.
摘要
钙振荡控制线粒体沿微管的运动，进而支持线粒体的按需分布。然而，介导Ca(2+)效应的机制仍是个谜。最近，几篇论文报道了一种将线粒体与驱动蛋白连接起来的Miro-Milton复合体对线粒体动力学的Ca(2+)依赖性调节。线粒体的运动性和融合-分裂动力学似乎都对该复合体的Ca(2+)依赖性开关敏感。越来越多的证据表明，通过Miro-Milton的钙信号传导对于局部氧化代谢与能量需求的协调以及防止Ca(2+)诱导的细胞损伤至关重要。
相似文献
1
Ca2+-dependent regulation of mitochondrial dynamics by the Miro-Milton complex.
Int J Biochem Cell Biol. 2009 Oct;41(10):1972-6. doi: 10.1016/j.biocel.2009.05.013. Epub 2009 May 27.
2
Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase.
Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20728-33. doi: 10.1073/pnas.0808953105. Epub 2008 Dec 19.
3
The mechanism of Ca2+ -dependent regulation of kinesin-mediated mitochondrial motility.
Cell. 2009 Jan 9;136(1):163-74. doi: 10.1016/j.cell.2008.11.046.
4
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.
Biochemistry. 2009 Mar 10;48(9):2045-52. doi: 10.1021/bi8019178.
5
A new mode of mitochondrial transport and polarized sorting regulated by Dynein, Milton and Miro.
Development. 2016 Nov 15;143(22):4203-4213. doi: 10.1242/dev.138289. Epub 2016 Oct 5.
6
TNFα decreases mitochondrial movement in human airway smooth muscle.
Am J Physiol Lung Cell Mol Physiol. 2017 Jul 1;313(1):L166-L176. doi: 10.1152/ajplung.00538.2016. Epub 2017 May 4.
7
APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane.
Mol Biol Cell. 2016 Feb 1;27(3):466-82. doi: 10.1091/mbc.E15-09-0632. Epub 2015 Dec 10.
8
Miro (Mitochondrial Rho GTPase), a key player of mitochondrial axonal transport and mitochondrial dynamics in neurodegenerative diseases.
Mitochondrion. 2021 Jan;56:118-135. doi: 10.1016/j.mito.2020.10.005. Epub 2020 Oct 28.
9
Regulation of long-distance transport of mitochondria along microtubules.
Cell Mol Life Sci. 2018 Jan;75(2):163-176. doi: 10.1007/s00018-017-2590-1. Epub 2017 Jul 12.
10
Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins.
Biochem Soc Trans. 2013 Dec;41(6):1525-31. doi: 10.1042/BST20130234.
引用本文的文献
1
Death-Associated Protein 3 Triggers Intrinsic Apoptosis via Miro1 Upon Inducing Intracellular Calcium Changes.
MedComm (2020). 2025 May 10;6(5):e70214. doi: 10.1002/mco2.70214. eCollection 2025 May.
2
Role of Mitochondrial Dysfunctions in Neurodegenerative Disorders: Advances in Mitochondrial Biology.
Mol Neurobiol. 2025 Jun;62(6):6827-6855. doi: 10.1007/s12035-024-04469-x. Epub 2024 Sep 13.
3
The Role of Mitochondrial Dynamics and Mitotic Fission in Regulating the Cell Cycle in Cancer and Pulmonary Arterial Hypertension: .
Cells. 2023 Jul 20;12(14):1897. doi: 10.3390/cells12141897.
4
Nano-positioning and tubulin conformation contribute to axonal transport regulation of mitochondria along microtubules.
Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2203499119. doi: 10.1073/pnas.2203499119. Epub 2022 Nov 2.
5
In Vitro Reconstitution of Molecular Motor-Driven Mitochondrial Transport.
Methods Mol Biol. 2022;2431:533-546. doi: 10.1007/978-1-0716-1990-2_28.
6
Serine/Threonine Protein Phosphatase 2A Regulates the Transport of Axonal Mitochondria.
Front Cell Neurosci. 2022 Mar 18;16:852245. doi: 10.3389/fncel.2022.852245. eCollection 2022.
7
Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives.
Cells. 2022 Feb 5;11(3):552. doi: 10.3390/cells11030552.
8
Quantitative analysis of mitochondrial morphologies in human induced pluripotent stem cells for Leigh syndrome.
Stem Cell Res. 2021 Dec;57:102572. doi: 10.1016/j.scr.2021.102572. Epub 2021 Oct 12.
9
MitoCellPhe reveals mitochondrial morphologies in single fibroblasts and clustered stem cells.
Am J Physiol Cell Physiol. 2021 Oct 1;321(4):C735-C748. doi: 10.1152/ajpcell.00231.2021. Epub 2021 Sep 1.
10
Dynamic regulation of mitochondrial-endoplasmic reticulum crosstalk during stem cell homeostasis and aging.
Cell Death Dis. 2021 Aug 16;12(9):794. doi: 10.1038/s41419-021-03912-4.
本文引用的文献
1
Drosophila Miro is required for both anterograde and retrograde axonal mitochondrial transport.
J Neurosci. 2009 Apr 29;29(17):5443-55. doi: 10.1523/JNEUROSCI.5417-08.2009.
2
Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses.
Neuron. 2009 Feb 26;61(4):541-55. doi: 10.1016/j.neuron.2009.01.030.
3
Moving or stopping mitochondria: Miro as a traffic cop by sensing calcium.
Neuron. 2009 Feb 26;61(4):493-6. doi: 10.1016/j.neuron.2009.02.003.
4
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.
Biochemistry. 2009 Mar 10;48(9):2045-52. doi: 10.1021/bi8019178.
5
The mechanism of Ca2+ -dependent regulation of kinesin-mediated mitochondrial motility.
Cell. 2009 Jan 9;136(1):163-74. doi: 10.1016/j.cell.2008.11.046.
6
GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons.
Mol Cell Neurosci. 2009 Mar;40(3):301-12. doi: 10.1016/j.mcn.2008.10.016. Epub 2008 Dec 3.
7
Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase.
Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20728-33. doi: 10.1073/pnas.0808953105. Epub 2008 Dec 19.
8
Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria.
Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15803-8. doi: 10.1073/pnas.0808249105. Epub 2008 Oct 6.
9
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila.
Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14503-8. doi: 10.1073/pnas.0803998105. Epub 2008 Sep 17.
10
CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology.
J Cell Biol. 2008 Aug 11;182(3):573-85. doi: 10.1083/jcb.200802164.
Zotero 插件