Gulder Tobias A M, Moore Bradley S
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, and the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093, USA.
Curr Opin Microbiol. 2009 Jun;12(3):252-60. doi: 10.1016/j.mib.2009.05.002. Epub 2009 May 28.
Bacterial marine natural products are an important source of novel lead structures for drug discovery. The cytotoxic properties of many of these secondary metabolites are of particular interest for the development of new anticancer agents. Tremendous advances in marine molecular biology, genome sequencing, and bioinformatics have paved the way to fully exploit the biomedical potential of marine bacterial products. In addition, unique biosynthetic enzymes discovered from bacteria from the sea have begun to emerge as powerful biocatalysts in medicinal chemistry and total synthesis. The increasingly interdisciplinary field of marine natural product chemistry thus strongly impacts future developments in medicine, chemistry, and biology.
海洋细菌天然产物是药物研发中新的先导结构的重要来源。这些次生代谢产物中的许多具有的细胞毒性特性对于新型抗癌药物的开发尤为重要。海洋分子生物学、基因组测序和生物信息学的巨大进展为充分挖掘海洋细菌产物的生物医学潜力铺平了道路。此外，从海洋细菌中发现的独特生物合成酶已开始在药物化学和全合成中成为强大的生物催化剂。因此，海洋天然产物化学这一日益跨学科的领域对医学、化学和生物学的未来发展产生了重大影响。
