Blazer Dan G, Wu Li-Tzy
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA.
J Am Geriatr Soc. 2009 Jul;57(7):1252-7. doi: 10.1111/j.1532-5415.2009.02306.x. Epub 2009 May 21.
To estimate the frequency, distribution, and correlates of nonprescription use of pain relievers by middle-aged and elderly persons in the United States.
Cross-sectional data analysis of a national community survey.
The 2005 and 2006 National Surveys on Drug Use and Health.
Ten thousand nine hundred fifty-three respondents aged 50 and older (6,717 aged 50-64 and 4,236 aged > or = 65).
Social and demographic variables, detailed assessment of nonprescription use (and abuse) of prescription pain relievers (e.g., acetaminophen with codeine, morphine), substance use, major depression, self-reported medical illnesses, and self-rated health.
A small proportion of the sample (1.4%) reported nonprescription use of prescription pain relievers during the previous year. Combinations of acetaminophen and hydrocodone or propoxyphene were the most commonly used drugs. Use was associated with younger age (odds ratio (OR)=2.39, 95% confidence interval (CI)=1.31-4.36), American Indian and Alaska native (OR=8.78, 95% CI=2.50-30.85), and use of marijuana (OR=7.07, 95% CI=3.99-12.53). Fewer than 10% of nonprescription users were abusing these medications or dependent upon them.
In a representative sample of middle-aged and older adults, nonprescription use of prescription pain relievers is relatively uncommon, but the much higher use by middle-aged adults suggests that, as this cohort ages, the problem may increase in elderly people.
评估美国中年及老年人非处方使用止痛剂的频率、分布情况及其相关因素。
对一项全国性社区调查进行横断面数据分析。
2005年和2006年全国药物使用和健康调查。
10953名年龄在50岁及以上的受访者(6717名年龄在50 - 64岁之间,4236名年龄在65岁及以上)。
社会和人口统计学变量、对处方止痛剂非处方使用(及滥用)的详细评估(如对乙酰氨基酚与可待因、吗啡)、物质使用情况、重度抑郁症、自我报告的疾病以及自我评估的健康状况。
样本中一小部分人(1.4%)报告在前一年非处方使用了处方止痛剂。对乙酰氨基酚与氢可酮或丙氧芬的组合是最常用的药物。使用与较年轻的年龄(优势比(OR)=2.39,95%置信区间(CI)=1.31 - 4.36)、美国印第安人和阿拉斯加原住民(OR=8.78,95% CI=2.50 - 30.85)以及使用大麻(OR=7.07,95% CI=3.99 - 12.53)有关。非处方使用者中不到10%的人滥用这些药物或对其有依赖。
在中年及老年人的代表性样本中,非处方使用处方止痛剂相对不常见,但中年成年人的使用比例高得多,这表明随着这一群体年龄增长,老年人中的这个问题可能会增加。