Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Int J Nanomedicine. 2011 Jan 6;6:93-100. doi: 10.2147/IJN.S13385.
In this study, new nano-fluor-hydroxyapatite (nFHA)/polyurethane composite scaffolds were fabricated for potential use in bone tissue engineering. Polyester urethane samples were synthesized from polycaprolactone, hexamethylene diisocyanate, and 1,4-butanediol as chain extender. Nano fluor-hydroxyapatite (nFHA) was successfully synthesized by sol-gel method. The solid-liquid phase separation and solvent sublimation methods were used for preparation of the porous composites. Mechanical properties, chemical structure, and morphological characteristics of the samples were investigated by compressive test, Fourier transform infrared, and scanning electron microscopy (SEM) techniques, respectively. The effect of nFHA powder content on porosity and pore morphology was investigated. SEM images demonstrated that the scaffolds were constituted of interconnected and homogeneously distributed pores. The pore size of the scaffolds was in the range 50-250 μm. The result obtained in this research revealed that the porosity and pore average size decreased and compressive modulus increased with nFHA percentage. Considering morphological, physical, and mechanical properties, the scaffold with a higher ratio of nFHA has suitable potential use in tissue regeneration.
在这项研究中，制备了新型纳米氟羟基磷灰石（nFHA）/聚氨酯复合支架，用于潜在的骨组织工程应用。聚酯型聚氨酯样品是由聚己内酯、六亚甲基二异氰酸酯和 1,4-丁二醇作为扩链剂合成的。通过溶胶-凝胶法成功合成了纳米氟羟基磷灰石（nFHA）。采用固-液相分离和溶剂升华法制备多孔复合材料。通过压缩试验、傅里叶变换红外光谱和扫描电子显微镜（SEM）技术分别研究了样品的力学性能、化学结构和形态特征。考察了 nFHA 粉末含量对多孔复合材料孔隙率和孔形貌的影响。SEM 图像表明，支架由相互连接且均匀分布的孔构成。支架的孔径在 50-250μm 范围内。本研究结果表明，随着 nFHA 百分含量的增加，多孔复合材料的孔隙率和平均孔径减小，压缩模量增大。考虑到形态、物理和机械性能，具有更高 nFHA 比例的支架在组织再生方面具有潜在的应用价值。
