Stoffman Nava, Gordon Catherine M
Adolescent Clinic, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.
Curr Opin Pediatr. 2009 Aug;21(4):465-71. doi: 10.1097/MOP.0b013e32832da096.
Vitamin D has become the focus of many studies in recent years. Vitamin D deficiency has been linked to many chronic illnesses other then the well known musculoskeletal complications. In this review, we summarize new data regarding causes, prevalence, and complications of vitamin deficiency in adolescents and discuss them in the context of what is known in adults. In addition, we emphasize adolescence as a unique period for growth and development, and distinguish the consequences of vitamin D deficiency in young teenage patients from those in adults with regard to the presentation and potential health implications.
Vitamin D deficiency is common among both healthy and ill adolescents worldwide, even in sunny countries. Although much of the data relating vitamin D status to biological markers and complications has been obtained in adults, the information emerging from studies of adolescents supports the premise that maintaining sufficient levels of vitamin D during the teenage years can improve long-term health outcomes. There are currently knowledge gaps regarding the most well tolerated and appropriate supplementation regimen to prevent vitamin D deficiency among adolescents.
Further studies are needed to examine the implications of vitamin D deficiency among adolescents and the most appropriate treatment regimens to prevent this problem. There are sufficient data to support the importance of educating, preventing, and treating vitamin D deficiency in adolescents to improve their long-term health.
近年来,维生素D已成为众多研究的焦点。除了众所周知的肌肉骨骼并发症外,维生素D缺乏还与许多慢性疾病有关。在本综述中,我们总结了有关青少年维生素缺乏的原因、患病率和并发症的新数据,并在成人已知情况的背景下进行讨论。此外,我们强调青春期是生长发育的独特时期,并在表现形式和潜在健康影响方面区分青少年维生素D缺乏的后果与成人的后果。
全球范围内,无论是健康青少年还是患病青少年,维生素D缺乏都很常见,即使在阳光充足的国家也是如此。尽管许多将维生素D状态与生物标志物和并发症相关的数据是在成人中获得的,但青少年研究得出的信息支持这样一个前提,即在青少年时期维持足够的维生素D水平可以改善长期健康结果。目前在预防青少年维生素D缺乏的最耐受和适当的补充方案方面存在知识空白。
需要进一步研究来探讨青少年维生素D缺乏的影响以及预防该问题的最适当治疗方案。有足够的数据支持对青少年进行维生素D缺乏的教育、预防和治疗以改善其长期健康的重要性。