Santi L
Dipartimento di Biologia, Università di Roma Tor Vergata, via della Ricerca Scientifica, 00133, Rome, Italy.
Vet Res Commun. 2009 Sep;33 Suppl 1:61-6. doi: 10.1007/s11259-009-9246-z.
Infectious diseases remain one of the main causes of death and economic losses in animals despite the fact that prophylactic vaccination has been extremely successful in disease prevention. New effective viral, bacterial and parasitic vaccines are needed, but unfortunately production costs still remain prohibitive. In this respect plants can offer a valid alternative. Production of antigenic proteins in plants relies on a well developed and proven technology, several expression platforms are available and many different plant species can be utilized. Plant based veterinary vaccine studies have addressed protection issues in model animals and, more interestingly, some of them have examined the relevant challenge model in the specific species of interest. A general overview of the topic will be outlined together with a few selected promising examples.
尽管预防性疫苗在疾病预防方面极为成功，但传染病仍是动物死亡和经济损失的主要原因之一。需要新的有效的病毒、细菌和寄生虫疫苗，但不幸的是，生产成本仍然高得令人望而却步。在这方面，植物可以提供一个有效的替代方案。在植物中生产抗原蛋白依赖于一项成熟且经过验证的技术，有多种表达平台可供使用，并且可以利用许多不同的植物物种。基于植物的兽用疫苗研究已经解决了模式动物中的保护问题，更有趣的是，其中一些研究已经在特定的目标物种中检验了相关的攻毒模型。本文将概述该主题的总体情况，并列举一些有前景的实例。
