Lorenzo Carlos, Williams Ken, Stern Michael P, Haffner Steven M
Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284-7873, USA.
Metabolism. 2009 Nov;58(11):1530-5. doi: 10.1016/j.metabol.2009.04.030. Epub 2009 Jul 7.
Mexican Americans are more obese and have more diabetes than non-Hispanic whites, but are also shorter. Height is used in some diabetes prediction models. Therefore, we examined the effect of height on the relationship between ethnicity and incident diabetes. Incident diabetes was ascertained in 1730 participants in the San Antonio Heart Study (age range, 25-64 years) after 7.4 years of follow-up. Height predicted diabetes in neither men (odds ratio [OR] x 1 SD, 1.14 [0.85-1.51]) nor women (OR x 1 SD, 0.88 [0.70-1.11]) after adjusting for age and ethnicity. The area under the receiver operating characteristic curve for predicting diabetes of a model that included waist circumference (in men, 0.775; in women, 0.781) was similar to that of models that included waist circumference + height (in men, 0.775, P = .702; in women, 0.783, P = .680) or waist-to-height ratio (in men, 0.764, P = .161; in women, 0.783, P = .619). The OR of incident diabetes according to ethnicity was lower in the model that was adjusted for the waist-to-height ratio than in the model that accounted only for waist circumference (in women, 1.45 [0.86-2.46] vs 1.84 [1.10-3.08], P < .001; in men, 2.00 [1.11-3.58] vs 2.74 [1.52-4.95], P < .001). In conclusion, the addition of height to adjust waist circumference does not increase the ability of waist circumference to predict diabetes, but may be useful in exploring differences in diabetic risk between populations of different race/ethnicity.
墨西哥裔美国人比非西班牙裔白人更肥胖，患糖尿病的几率也更高，但他们的身高也更矮。身高被用于一些糖尿病预测模型中。因此，我们研究了身高对种族与新发糖尿病之间关系的影响。在圣安东尼奥心脏研究中，对1730名参与者（年龄范围25 - 64岁）进行了7.4年的随访，以确定新发糖尿病情况。在调整年龄和种族因素后，身高在男性（优势比[OR]×1标准差，1.14[0.85 - 1.51]）和女性（OR×1标准差，0.88[0.70 - 1.11]）中均不能预测糖尿病。包含腰围的糖尿病预测模型的受试者工作特征曲线下面积（男性为0.775，女性为0.781）与包含腰围 + 身高的模型（男性为0.775，P = 0.702；女性为0.783，P = 0.680）或腰高比的模型（男性为0.764，P = 0.161；女性为0.783，P = 0.619）相似。根据种族调整腰高比的模型中，新发糖尿病的OR低于仅考虑腰围的模型（女性中，1.45[0.86 - 2.46]对1.84[1.10 - 3.08]，P < 0.001；男性中，2.00[1.11 - 3.58]对2.74[1.52 - 4.95]，P < 0.001）。总之，增加身高来调整腰围并不能提高腰围预测糖尿病的能力，但可能有助于探索不同种族/民族人群之间糖尿病风险的差异。
