黑曲霉组物种的物种鉴定及抗真菌药敏模式
Species identification and antifungal susceptibility patterns of species belonging to Aspergillus section Nigri.
作者信息
Alcazar-Fuoli Laura, Mellado Emilia, Alastruey-Izquierdo Ana, Cuenca-Estrella Manuel, Rodriguez-Tudela Juan L
机构信息
Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
出版信息
Antimicrob Agents Chemother. 2009 Oct;53(10):4514-7. doi: 10.1128/AAC.00585-09. Epub 2009 Jul 27.
Abstract
A phylogenetic analysis was performed for 34 Aspergillus strains belonging to section Nigri. Molecular methods allowed for the correct classification into three different clades (A. niger, A. tubingensis, and A. foetidus). Correlation with in vitro itraconazole susceptibility distinguished the following three profiles: susceptible, resistant, and showing a paradoxical effect. A number of different species whose morphological features resemble those of A. niger showed unusual MICs to itraconazole that have never been described for the Aspergillus genus.
摘要
对属于黑曲霉组的34株曲霉菌株进行了系统发育分析。分子方法能够将其正确分类为三个不同的进化枝（黑曲霉、烟曲霉和臭曲霉）。与体外伊曲康唑敏感性的相关性区分出以下三种情况：敏感、耐药和呈现矛盾效应。一些形态特征与黑曲霉相似的不同物种对伊曲康唑显示出曲霉属中从未描述过的异常最低抑菌浓度。
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