Ahmed Tanvir, Das Sai Krupa, Golden Julie K, Saltzman Edward, Roberts Susan B, Meydani Simin Nikbin
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
J Gerontol A Biol Sci Med Sci. 2009 Nov;64(11):1107-13. doi: 10.1093/gerona/glp101. Epub 2009 Jul 28.
Calorie restriction (CR) enhances immune response and prolongs life span in animals. However, information on the applicability of these results to humans is limited. T-cell function declines with age. We examined effects of CR on T-cell function in humans. Forty-six overweight, nonobese participants aged 20-42 years were randomly assigned to 30% or 10% CR group for 6 months. Delayed-type hypersensitivity (DTH), T-cell proliferation (TP), and prostaglandin E(2) (PGE(2)) productions were determined before and after CR. DTH and TP to T-cell mitogens were increased in both groups over baseline (p < or = .019). However, number of positive responses to DTH antigens (p = .016) and TP to anti-CD3 reached statistical significance only after 30% CR (p = .001). Lipopolysaccharide-stimulated PGE(2) was reduced in both groups but reached statistical significance after 30% CR (p < or = .029). These results, for the first time, show that 6-month CR in humans improves T-cell function.
热量限制（CR）可增强动物的免疫反应并延长其寿命。然而，关于这些结果在人类中的适用性的信息有限。T细胞功能会随着年龄的增长而下降。我们研究了热量限制对人类T细胞功能的影响。46名年龄在20至42岁之间的超重但不肥胖的参与者被随机分配到30%或10%热量限制组，为期6个月。在热量限制前后分别测定迟发型超敏反应（DTH）、T细胞增殖（TP）和前列腺素E2（PGE2）的产生情况。两组中针对T细胞有丝分裂原的DTH和TP均高于基线水平（p≤0.019）。然而，仅在30%热量限制后，对DTH抗原的阳性反应数量（p = 0.016）和针对抗CD3的TP才达到统计学显著性（p = 0.001）。两组中脂多糖刺激产生的PGE2均减少，但仅在30%热量限制后达到统计学显著性（p≤0.029）。这些结果首次表明，人类进行6个月的热量限制可改善T细胞功能。
