Alziar I, Bonniaud G, Couanet D, Ruaud J B, Vicente C, Giordana G, Ben-Harrath O, Diaz J C, Grandjean P, Kafrouni H, Chavaudra J, Lefkopoulos D, de Vathaire F, Diallo I
U605 INSERM, Villejuif, France. IFR69, Villejuif, France. Université Paris XI, Villejuif, France. Institut Gustave-Roussy, Villejuif, France.
Phys Med Biol. 2009 Sep 7;54(17):N375-83. doi: 10.1088/0031-9155/54/17/N01. Epub 2009 Aug 4.
This study presents a method aimed at creating radiotherapy (RT) patient-adjustable whole-body phantoms to permit retrospective and prospective peripheral dose evaluations for enhanced patient radioprotection. Our strategy involves virtual whole-body patient models (WBPM) in different RT treatment positions for both genders and for different age groups. It includes a software tool designed to match the anatomy of the phantoms with the anatomy of the actual patients, based on the quality of patient data available. The procedure for adjusting a WBPM to patient morphology includes typical dimensions available in basic auxological tables for the French population. Adjustment is semi-automatic. Because of the complexity of the human anatomy, skilled personnel are required to validate changes made in the phantom anatomy. This research is part of a global project aimed at proposing appropriate methods and software tools capable of reconstituting the anatomy and dose evaluations in the entire body of RT patients in an adapted treatment planning system (TPS). The graphic user interface is that of a TPS adapted to obtain a comfortable working process. Such WBPM have been used to supplement patient therapy planning images, usually restricted to regions involved in treatment. Here we report, as an example, the case of a patient treated for prostate cancer whose therapy planning images were complemented by an anatomy model. Although present results are preliminary and our research is ongoing, they appear encouraging, since such patient-adjusted phantoms are crucial in the optimization of radiation protection of patients and for follow-up studies.
本研究提出了一种方法，旨在创建可由放疗（RT）患者自行调整的全身体模，以便进行回顾性和前瞻性外周剂量评估，从而加强对患者的辐射防护。我们的策略涉及针对不同性别和不同年龄组在不同RT治疗体位下的虚拟全身患者模型（WBPM）。它包括一个软件工具，该工具旨在根据可用患者数据的质量，使体模的解剖结构与实际患者的解剖结构相匹配。将WBPM调整为患者形态的程序包括法国人群基础人体测量表中的典型尺寸。调整是半自动的。由于人体解剖结构的复杂性，需要技术熟练的人员来验证体模解剖结构中所做的更改。本研究是一个全球项目的一部分，该项目旨在提出合适的方法和软件工具，以便在适配的治疗计划系统（TPS）中重建RT患者全身的解剖结构并进行剂量评估。图形用户界面是一个经过适配的TPS的界面，以获得舒适的工作流程。此类WBPM已被用于补充患者治疗计划图像，这些图像通常仅限于治疗涉及的区域。在此，我们举例报告了一名前列腺癌患者的病例，其治疗计划图像通过解剖模型得到了补充。尽管目前的结果是初步的且我们的研究仍在进行中，但它们看起来很令人鼓舞，因为这种经患者调整的体模对于优化患者的辐射防护以及后续研究至关重要。
