2001 年至 2007 年期间，美国不同年龄和地理位置的患者血液中光滑念珠菌分离株对氟康唑敏感性的变化。
Variation in susceptibility of bloodstream isolates of Candida glabrata to fluconazole according to patient age and geographic location in the United States in 2001 to 2007.
机构信息
Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA.
出版信息
J Clin Microbiol. 2009 Oct;47(10):3185-90. doi: 10.1128/JCM.00946-09. Epub 2009 Aug 5.
Abstract
We examined the susceptibilities to fluconazole of 642 bloodstream infection (BSI) isolates of Candida glabrata and grouped the isolates by patient age and geographic location within the United States. Susceptibility of C. glabrata to fluconazole was lowest in the northeast region (46%) and was highest in the west (76%). The frequencies of isolation and of fluconazole resistance among C. glabrata BSI isolates were higher in the present study (years 2001 to 2007) than in a previous study conducted from 1992 to 2001. Whereas the frequency of C. glabrata increased with patient age, the rate of fluconazole resistance declined. The oldest age group (> or = 80 years) had the highest proportion of BSI isolates that were C. glabrata (32%) and the lowest rate of fluconazole resistance (5%).
摘要
我们研究了 642 株光滑念珠菌血流感染（BSI）分离株对氟康唑的敏感性，并根据患者年龄和美国地理位置对分离株进行分组。光滑念珠菌对氟康唑的敏感性在东北部最低（46%），在西部最高（76%）。与 1992 年至 2001 年进行的先前研究相比，本研究（2001 年至 2007 年）中光滑念珠菌 BSI 分离株的分离和氟康唑耐药率更高。尽管光滑念珠菌的频率随患者年龄的增加而增加，但氟康唑的耐药率却下降了。年龄最大的组（≥80 岁）BSI 分离株中光滑念珠菌的比例最高（32%），氟康唑耐药率最低（5%）。
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