Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, 10002, Taiwan,
Hepatol Int. 2009 Jun;3(2):364-70. doi: 10.1007/s12072-008-9111-0. Epub 2008 Dec 2.
Adiponectin possesses anti-inflammatory and insulin-sensitizing properties. Little is known about the role of adiponectin in hepatitis B-related liver disease.
Serum adiponectin and hepatitis B viral factors were cross-sectionally assayed in 280 patients with chronic hepatitis B virus (HBV) infection including 120 patients with chronic HBV infection, 40 patients with cirrhosis, and 120 patients with hepatocellular carcinoma (HCC); 116 healthy adults were used as controls. The dynamics of serum adiponectin level was also studied longitudinally in 25 patients with hepatitis B e antigen (HBeAg) seroconversion (SC).
We found that serum adiponectin level in patients with chronic HBV infection was similar to that in healthy controls and was significantly lower than patients with cirrhosis and HCC. In univariate analysis, high serum adiponectin level significantly correlated with the presence of HBV-related cirrhosis or HCC, abnormal serum ALT level, and HBV genotype C. Multivariate analysis revealed that high serum adiponectin level significantly correlated with the development of HCC. Serum adiponectin levels remained stationary in patients experiencing HBeAg SC.
Our findings suggest that HBV infection itself does not affect adiponectin levels. Serum adiponectin level correlates with the progression of HBV-related liver diseases but not with the development of HBeAg SC.
脂联素具有抗炎和胰岛素增敏作用。关于脂联素在乙型肝炎相关肝病中的作用知之甚少。
在 280 例慢性乙型肝炎病毒（HBV）感染者中，包括 120 例慢性 HBV 感染者、40 例肝硬化患者和 120 例肝细胞癌（HCC）患者，对血清脂联素和乙型肝炎病毒因子进行了横断面检测；116 名健康成年人作为对照。还对 25 例乙型肝炎 e 抗原（HBeAg）血清学转换（SC）患者进行了血清脂联素水平的纵向研究。
我们发现，慢性 HBV 感染者的血清脂联素水平与健康对照组相似，明显低于肝硬化和 HCC 患者。单因素分析显示，高血清脂联素水平与 HBV 相关肝硬化或 HCC、异常血清 ALT 水平和 HBV 基因型 C 的存在显著相关。多因素分析显示，高血清脂联素水平与 HCC 的发生显著相关。在 HBeAg SC 患者中，血清脂联素水平保持稳定。
我们的研究结果表明，HBV 感染本身并不影响脂联素水平。血清脂联素水平与 HBV 相关肝病的进展相关，但与 HBeAg SC 的发生无关。
