口腔鳞状细胞癌患者唾液中的人乳头瘤病毒。
Human papillomavirus in saliva of patients with oral squamous cell carcinoma.
机构信息
Department of Oral Medicine, Faculty of Dentistry, Tehran University of Medical Science, Tehran, Iran.
出版信息
Med Oral Patol Oral Cir Bucal. 2009 Oct 1;14(10):e525-8. doi: 10.4317/medoral.14.e525.
OBJECTIVE
The aim of this study was to evaluate the presence of human papillomavirus (HPV) in saliva rinses of patients with oral squamous cell carcinoma and to analyze the possibility of using saliva as a diagnostic method for screening high-risk patients.
STUDY DESIGN
The saliva sample of 22 patients with oral squamous cell carcinoma and 20 age-sex matched healthy controls were obtained. The presence of HPV 6, 11, 16, 18, 31, and 33 was evaluated by polymerase chain reaction (PCR).
RESULTS
In 40.9% of the patients and in 25% of the controls, the saliva was shown to be positive for HPV. In 27.3% of the patients and in 20% of the controls, the saliva was shown to be positive for HPV16; and none of the controls, except one patient was shown to be positive for HPV 18. Neither patients nor controls were positive for HPV 31 and 33. These differences were not statistically significant.
CONCLUSIONS
The results of this study were unable to support the detection of HPV in saliva rinses as a diagnostic method for OSCC.
目的
本研究旨在评估口腔鳞状细胞癌患者唾液冲洗液中人乳头瘤病毒（HPV）的存在，并分析唾液作为筛查高危患者的诊断方法的可能性。
研究设计
采集 22 例口腔鳞状细胞癌患者和 20 例年龄性别匹配的健康对照者的唾液样本。采用聚合酶链反应（PCR）检测 HPV 6、11、16、18、31 和 33 的存在。
结果
40.9%的患者和 25%的对照组唾液 HPV 阳性。27.3%的患者和 20%的对照组唾液 HPV16 阳性；对照组除 1 例患者外，均未检测到 HPV18 阳性。患者和对照组均未检测到 HPV31 和 33。这些差异无统计学意义。
结论
本研究结果不能支持检测唾液冲洗液中的 HPV 作为口腔鳞状细胞癌的诊断方法。
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