Rodrigues Eduardo B, Costa Elaine F, Penha Fernando M, Melo Gustavo B, Bottós Juliana, Dib Eduardo, Furlani Bruno, Lima Veronica C, Maia Maurício, Meyer Carsten H, Höfling-Lima Ana Luisa, Farah Michel E
Vision Institute IPEPO, Department of Ophthalmology, Federal University of São Paulo, Brazil.
Surv Ophthalmol. 2009 Sep-Oct;54(5):576-617. doi: 10.1016/j.survophthal.2009.04.011.
Vital dyes have advanced diagnosis and surgical technique in various specialties, including oncology, gastroenterology, and ophthalmology. In ocular surgery vital dyes are widely used in cataract and vitreoretinal surgery. Worldwide, intra-operative use of trypan blue during cataract surgery has enhanced visualization of the anterior capsule during capsulorrhexis, and patent blue has been recently licensed in Europe for cataract surgery. For chromovitrectomy, the vital dyes indocyanine green, infracyanine green, and brilliant blue stain the internal limiting membrane, and trypan blue and triamcinolone acetonide help visualize epiretinal membranes and vitreous, respectively. Intra-operative vital dyes are finding uses in corneal, glaucoma, orbit, strabismus, and conjunctival surgery. We provide a summary of current knowledge of the use of vital dyes in ocular surgery. We review the properties of dyes, techniques of application, indications, and complications in ocular surgery. Vital dyes represent an expanding area of research, and novel dyes deserve further investigation.
活性染料推动了包括肿瘤学、胃肠病学和眼科在内的各个专业的诊断和手术技术发展。在眼科手术中，活性染料广泛应用于白内障和玻璃体视网膜手术。在全球范围内，白内障手术中术中使用台盼蓝可增强撕囊过程中前囊膜的可视化，专利蓝最近在欧洲已获许可用于白内障手术。对于染色玻璃体视网膜手术，活性染料吲哚菁绿、亚甲蓝绿和亮蓝可对视网膜内界膜进行染色，而台盼蓝和曲安奈德分别有助于使视网膜前膜和玻璃体可视化。术中活性染料正在角膜、青光眼、眼眶、斜视和结膜手术中得到应用。我们总结了目前活性染料在眼科手术中应用的相关知识。我们回顾了染料的特性、应用技术、适应症以及眼科手术中的并发症。活性染料是一个不断扩展的研究领域，新型染料值得进一步研究。
