Baggott Christina, Dodd Marylin, Kennedy Christine, Marina Neyssa, Miaskowski Christine
Department of Physiological Nursing at the University of California, San Francisco, USA.
J Pediatr Oncol Nurs. 2009 Nov-Dec;26(6):325-39. doi: 10.1177/1043454209340324. Epub 2009 Aug 17.
Clinical experience suggests that children with cancer experience multiple symptoms as a result of their disease and/ or its treatment. These symptoms may have a negative impact on children's ability to function and on their quality of life. No systematic review has summarized the findings from studies that assessed multiple symptoms in these patients. The purposes of this article are to summarize the findings from the studies of multiple symptoms in pediatric oncology patients and to describe directions for future research. Although there has been a recent increase in the studies of the multiple symptoms in pediatric cancer patients, only 9 studies were found that met the inclusion criteria for this review. Thus, little is known about the relationships between demographic and clinical characteristics and the occurrence of multiple symptoms. Additional research is warranted on the prevalence and impact of multiple symptoms, particularly among homogeneous samples of patients. Future directions for symptom studies in pediatric oncology include symptom cluster research and the search for biological bases for the untoward effects of cancer treatment.
临床经验表明，患癌症的儿童会因疾病本身和/或其治疗而出现多种症状。这些症状可能会对儿童的身体机能和生活质量产生负面影响。尚无系统性综述总结评估这些患者多种症状的研究结果。本文的目的是总结儿科肿瘤患者多种症状的研究结果，并描述未来的研究方向。尽管近期对儿科癌症患者多种症状的研究有所增加，但仅发现9项研究符合本综述的纳入标准。因此，对于人口统计学和临床特征与多种症状发生之间的关系知之甚少。有必要针对多种症状的患病率及其影响开展更多研究，尤其是在同质化患者样本中。儿科肿瘤症状研究的未来方向包括症状群研究以及探寻癌症治疗不良反应的生物学基础。
