一体式生物微流控芯片的设计与集成。
Design and integration of an all-in-one biomicrofluidic chip.
出版信息
Biomicrofluidics. 2008 Jul 21;2(3):34103. doi: 10.1063/1.2966453.
Abstract
We demonstrate a highly integrated microfluidic chip with the function of DNA amplification. The integrated chip combines giant electrorheological-fluid actuated micromixer and micropump with a microheater array, all formed using soft lithography. Internal functional components are based on polydimethylsiloxane (PDMS) and silvercarbon black-PDMS composites. The system has the advantages of small size with a high degree of integration, high polymerase chain reaction efficiency, digital control and simple fabrication at low cost. This integration approach shows promise for a broad range of applications in chemical synthesis and biological sensinganalysis, as different components can be combined to target desired functionalities, with flexible designs of different microchips easily realizable through soft lithography.
摘要
我们展示了一种具有 DNA 扩增功能的高度集成微流控芯片。该集成芯片结合了巨电流变液驱动的微混合器和微泵以及微加热器阵列，所有这些都是通过软光刻技术形成的。内部功能组件基于聚二甲基硅氧烷（PDMS）和银碳黑-PDMS 复合材料。该系统具有小尺寸、高度集成、高聚合酶链反应效率、数字控制和低成本简单制造的优点。这种集成方法有望在化学合成和生物传感分析等广泛应用中得到应用，因为可以将不同的组件组合起来以实现所需的功能，并且可以通过软光刻轻松实现不同微芯片的灵活设计。
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