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分枝杆菌巯基葡萄糖的生物合成酶的结构和机制。

Structures and mechanisms of the mycothiol biosynthetic enzymes.

机构信息

Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

出版信息

Curr Opin Chem Biol. 2009 Oct;13(4):451-9. doi: 10.1016/j.cbpa.2009.07.018. Epub 2009 Aug 19.

DOI:10.1016/j.cbpa.2009.07.018
PMID:19699138
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2749902/
Abstract

In the past decade, the genes encoding all four enzymes responsible for the biosynthesis of mycothiol in Mycobacterium tuberculosis have been identified. Orthologs of each of these have been stably expressed and structurally characterized. The chemical mechanisms of all the four have also been studied. Because of the unique phylogenetic distribution of mycothiol, and the enzymes responsible for its biosynthesis, these enzymes represent interesting potential targets for antimycobacterial agents.

摘要

在过去的十年中，编码分枝杆菌属分枝杆菌生物合成菌巯基葡萄糖的所有四种酶的基因已被鉴定出来。这些酶的同源物已被稳定表达并进行了结构特征分析。四种酶的化学机制也已被研究。由于菌巯基葡萄糖及其生物合成酶独特的系统发育分布，这些酶代表了抗分枝杆菌药物的有趣的潜在靶标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/112f/2749902/a8b10f3da4a8/nihms136365f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/112f/2749902/8e719a497af5/nihms136365f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/112f/2749902/a41dfe26edd4/nihms136365f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/112f/2749902/6d766c6bcddb/nihms136365f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/112f/2749902/e404c71d6b6f/nihms136365f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/112f/2749902/a8b10f3da4a8/nihms136365f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/112f/2749902/8e719a497af5/nihms136365f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/112f/2749902/a41dfe26edd4/nihms136365f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/112f/2749902/6d766c6bcddb/nihms136365f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/112f/2749902/e404c71d6b6f/nihms136365f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/112f/2749902/a8b10f3da4a8/nihms136365f5.jpg

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