Skin and Laser Center, Potsdam, Germany.
J Eur Acad Dermatol Venereol. 2010 Mar;24(3):281-92. doi: 10.1111/j.1468-3083.2009.03409.x. Epub 2009 Sep 8.
BACKGROUND/OBJECTIVES: Peelings are among the oldest and most widespread aesthetic procedures used in aesthetic dermatology worldwide. More than 50 commercial peelings are currently available on the European market.
In the present review, we summarise the current knowledge on chemical peels.
RESULTS/CONCLUSIONS: A state-of-the-art peeling procedure will take into account the depth of the targeted structure and the skin condition of the patient to choose carefully among the variables such as chemical class of the peeling agent, concentration, frequency and pressure of the application. The usual classification of chemical peels comprises superficial, medium and deep peels. For superficial peels alpha-hydroxy-acids and most recently lipo-hydroxy acid are used to induce an exfoliation of the epidermis. Medium-depth agents such as trichloroacetic acid (<50%) cause an epidermal to papillary dermal peel and regeneration. Deep peels using trichloroacetic acid (>50%) or phenol based formulations reach the reticular dermis to induce dermal regeneration. The success of any peel is crucially dependent on the physicians understanding of the chemical and biological processes, as well as of indications, clinical effectiveness and side effects of the procedures.
背景/目的：化学焕肤术是全球皮肤科美学中最古老、应用最广泛的美容手段之一。目前，欧洲市场上有 50 多种商业性化学焕肤制剂。
本文综述了化学焕肤的最新知识。
结果/结论：先进的焕肤术将根据目标结构的深度和患者的皮肤状况，仔细考虑化学焕肤制剂的化学类别、浓度、应用频率和压力等变量，选择合适的焕肤术。常用的化学焕肤分类包括表浅性、中层和深层焕肤。表浅性焕肤使用α-羟酸和最近的新型脂羟酸，促使表皮剥脱。中层次之的焕肤制剂如三氯乙酸（<50%），可导致表皮至乳头真皮层的剥落和再生。使用三氯乙酸（>50%）或基于苯酚的制剂的深层焕肤可到达网状真皮，以诱导真皮再生。任何一种焕肤术的成功都取决于医生对化学和生物学过程以及适应证、临床疗效和副作用的理解。
