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Time-series transcriptomic analysis reveals novel gene modules that control theanine biosynthesis in tea plant (Camellia sinensis).时间序列转录组分析揭示了控制茶树（Camellia sinensis）茶氨酸生物合成的新型基因模块。
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本文引用的文献

1
Inhibitory effects of theanine and sera from theanine-fed rats on receptor-mediated cancer cell invasion beneath mesothelial-cell monolayers.茶氨酸及其在茶氨酸喂养大鼠血清对跨间皮细胞单层的受体介导的癌细胞侵袭的抑制作用。
Cytotechnology. 2001 Jul;36(1-3):195-200. doi: 10.1023/A:1014005423181.
2
Effects of green, oolong and black teas and related components on the proliferation and invasion of hepatoma cells in culture.绿茶、乌龙茶和红茶及其相关成分对培养的肝癌细胞增殖和侵袭的影响。
Cytotechnology. 1999 Sep;31(1-2):37-44. doi: 10.1023/A:1008076306672.
3
Structure-activity relationships of tea compounds against human cancer cells.茶化合物对人类癌细胞的构效关系。
J Agric Food Chem. 2007 Jan 24;55(2):243-53. doi: 10.1021/jf062276h.
4
Constitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallate.A549细胞中Nrf2依赖性血红素加氧酶-1的组成型过表达有助于其对表没食子儿茶素3-没食子酸酯诱导的细胞凋亡产生抗性。
J Biol Chem. 2006 Nov 3;281(44):33761-72. doi: 10.1074/jbc.M604748200. Epub 2006 Sep 1.
5
Effects of dietary powdered green tea and theanine on tumor growth and endogenous hyperlipidemia in hepatoma-bearing rats.膳食绿茶粉和茶氨酸对荷肝癌大鼠肿瘤生长及内源性高脂血症的影响。
Biosci Biotechnol Biochem. 2002 Apr;66(4):711-6. doi: 10.1271/bbb.66.711.
6
Effect of dihydrokainate on the antitumor activity of doxorubicin.二氢海因酸盐对阿霉素抗肿瘤活性的影响。
Cancer Lett. 2002 May 28;179(2):157-63. doi: 10.1016/s0304-3835(02)00012-5.
7
Membrane transport and antitumor activity of pirarubicin, and comparison with those of doxorubicin.吡柔比星的膜转运与抗肿瘤活性及其与多柔比星的比较
Jpn J Cancer Res. 1999 Jul;90(7):775-80. doi: 10.1111/j.1349-7006.1999.tb00814.x.
8
Time-dependent changes of amino acids in the serum, liver, brain and urine of rats administered with theanine.给予茶氨酸的大鼠血清、肝脏、大脑和尿液中氨基酸的时间依赖性变化。
Biosci Biotechnol Biochem. 1999 Apr;63(4):615-8. doi: 10.1271/bbb.63.615.
9
Enhancing effects of green tea components on the antitumor activity of adriamycin against M5076 ovarian sarcoma.绿茶成分对阿霉素抗M5076卵巢肉瘤抗肿瘤活性的增强作用。
Cancer Lett. 1998 Nov 13;133(1):19-26. doi: 10.1016/s0304-3835(98)00185-2.
10
Transmural potential changes associated with the in vitro absorption of theanine in the guinea pig intestine.与豚鼠肠道中茶氨酸体外吸收相关的跨壁电位变化。
Biosci Biotechnol Biochem. 1996 Nov;60(11):1768-71. doi: 10.1271/bbb.60.1768.

茶氨酸对人肺癌和白血病细胞生长以及人肺癌细胞迁移和侵袭的影响。

Effects of theanine on growth of human lung cancer and leukemia cells as well as migration and invasion of human lung cancer cells.

机构信息

Laboratory of Molecular Pharmacology, School of Pharmacy, Yantai University, No. 30, Qing Quan Lu, Lai Shan Qu, 264005, Yantai, Shandong, China.

出版信息

Cytotechnology. 2009 Apr;59(3):211-7. doi: 10.1007/s10616-009-9223-y. Epub 2009 Sep 17.

DOI:10.1007/s10616-009-9223-y
PMID:19760127
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2774573/
Abstract

The aim of this study is to investigate the effects of theanine, a tea characteristic amino acid, on human lung cancer and leukemia cells. In the present study, we have demonstrated that theanine suppressed the in vitro and ex vivo growth of human non-small cell lung cancer A549 and leukemia K562 cell lines in dose- and time-dependant manners. In addition, theanine displayed the inhibitory effect on the migration of A549 cells. More importantly, theanine enhanced the anticancer activity of anticancer agents such as trichostatin A (the histone deacetylase inhibitor), berbamine and norcantharidin (the anticancer drugs in China) by strongly reducing the viability and/or migration rate in A549 cells. In addition, theanine significantly suppressed A549 cell invasion. Suppression of A549 cell migration may be one of the important mechanisms of action of theanine against the A549 cell invasion. Our present results suggest that theanine may have the wide therapeutic and/or adjuvant therapeutic application in the treatment of human lung cancer and leukemia.

摘要

本研究旨在探讨茶氨酸——一种茶叶特有的氨基酸——对人类肺癌和白血病细胞的影响。在本研究中，我们已经证明茶氨酸以剂量和时间依赖的方式抑制体外和体内非小细胞肺癌 A549 和白血病 K562 细胞系的生长。此外，茶氨酸对 A549 细胞的迁移具有抑制作用。更重要的是，茶氨酸通过强烈降低 A549 细胞中的活力和/或迁移率，增强了曲古抑菌素 A（组蛋白去乙酰化酶抑制剂）、小檗胺和斑蝥素（中国的抗癌药物）等抗癌剂的抗癌活性。此外，茶氨酸还显著抑制了 A549 细胞的侵袭。抑制 A549 细胞迁移可能是茶氨酸抑制 A549 细胞侵袭的重要作用机制之一。我们的研究结果表明，茶氨酸可能在治疗人类肺癌和白血病方面具有广泛的治疗和/或辅助治疗应用前景。