Wolfson School of Mechanical and Manufacturing Engineering, Loughborough University, Loughborough, LE11 3TU, UK.
J Mater Sci Mater Med. 2010 Feb;21(2):815-21. doi: 10.1007/s10856-009-3882-2. Epub 2009 Sep 27.
The adhesion of microbes to catheter surfaces is a serious problem and the resulting infections frequently lead to longer hospitalisation and higher risk for the patient. Several approaches have been developed to produce materials that are less susceptible to microbial colonisation. One such approach is the incorporation of photoactivated compounds, such as Toluidine Blue O (TBO), in the polymeric matrix resulting in 'light-activated antimicrobial materials'. The insertion and removal of catheters can cause tissue damage and patient discomfort through frictional forces; hence the lubricity of a catheter material is also very important. In this work the tribological performance of silicone and polyurethane containing TBO and gold nanoparticles were evaluated using two different surfaces, the inner part of the aorta and the superior vena cava of sheep. Static and kinetic friction coefficients of these materials were measured using a tribometric device developed for in vitro applications using dry materials and those lubricated with blood. It was found that neither the preparation process nor the presence of TBO or gold nanoparticles, had an effect on the friction factors in comparison to those of untreated materials. In all cases, static and kinetic friction coefficients on aorta tissue were higher than those on vena cava due to higher surface roughness of the aorta. The presence of blood as a lubricant resulted in lower friction coefficients.
微生物黏附在导管表面是一个严重的问题，由此导致的感染经常会导致患者住院时间延长和风险增加。已经开发出几种方法来生产不易被微生物定植的材料。其中一种方法是在聚合物基质中加入光激活化合物，如甲苯胺蓝 O（TBO），从而形成“光激活抗菌材料”。导管的插入和取出会通过摩擦力对组织造成损伤并给患者带来不适；因此，导管材料的润滑性也非常重要。在这项工作中，使用两种不同的表面，即绵羊的主动脉内部分和上腔静脉，评估了含有 TBO 和金纳米粒子的硅酮和聚氨酯的摩擦学性能。使用为体外应用开发的摩擦计设备，测量了这些材料的静摩擦系数和动摩擦系数，这些材料是使用干燥材料和用血液润滑的材料进行测量的。结果发现，与未处理的材料相比，无论是制备过程还是 TBO 或金纳米粒子的存在，都不会影响摩擦系数。在所有情况下，由于主动脉的表面粗糙度较高，在主动脉组织上的静摩擦系数和动摩擦系数均高于在上腔静脉上的摩擦系数。作为润滑剂的血液的存在会导致摩擦系数降低。
