半枝莲中具有细胞毒活性的新克罗烷二萜类化合物。

neo-Clerodane diterpenoids from Scutellaria barbata with cytotoxic activities.

作者信息

Dai Sheng-Jun, Tao Jia-Yi, Liu Ke, Jiang Yong-Tao, Shen Li

机构信息

School of Pharmaceutical Science, Yantai University, Yantai 264005, People's Republic of China.

出版信息

Phytochemistry. 2006 Jul;67(13):1326-30. doi: 10.1016/j.phytochem.2006.04.024.

DOI:10.1016/j.phytochem.2006.04.024

PMID:16769097

Abstract

Three neo-clerodane diterpenoids, named barbatins A-C (1-3), and the neo-clerodane diterpenoid nicotinyl ester, named scutebarbatine B (4), were isolated from the whole plant of Scutellaria barbata D. Don. Their structures were elucidated by spectroscopic analyses (UV, IR, HRFAB-MS, 1D NMR and 2D NMR). In vitro, compounds 1-4 showed significant cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, with IC50 values in the range 3.5-8.1 microM.

摘要

从半枝莲（Scutellaria barbata D. Don）全草中分离出三种新克罗烷二萜类化合物，命名为半枝莲素A - C（1 - 3），以及一种新克罗烷二萜类烟酰酯，命名为黄芩半枝莲碱B（4）。通过光谱分析（紫外、红外、高分辨快原子轰击质谱、一维核磁共振和二维核磁共振）确定了它们的结构。在体外，化合物1 - 4对三种人类癌细胞系，即HONE - 1鼻咽癌、KB口腔表皮样癌和HT29结肠癌细胞显示出显著的细胞毒性活性，IC50值在3.5 - 8.1微摩尔范围内。