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杜波依斯念珠菌的反常生长并不排除对棘白菌素类治疗的体内反应。

Paradoxical growth of Candida dubliniensis does not preclude in vivo response to echinocandin therapy.

机构信息

Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain.

出版信息

Antimicrob Agents Chemother. 2009 Dec;53(12):5297-9. doi: 10.1128/AAC.00980-09. Epub 2009 Sep 28.

DOI:10.1128/AAC.00980-09
PMID:19786599
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2786325/
Abstract

Candida dubliniensis commonly shows paradoxical or trailing growth effects in vitro in the presence of echinocandins. We tested the in vitro activities of anidulafungin, caspofungin, and micafungin against clinical isolates of C. dubliniensis and evaluated the efficacy of these drugs in two murine models of systemic infection. The three echinocandins were similarly effective in the treatment of experimental disseminated infections with C. dubliniensis strains showing or not showing abnormal growth in vitro.

摘要

杜伯氏念珠菌在体外接触棘白菌素类药物时通常表现出反常或拖曳样生长效应。我们检测了棘白菌素类药物中的阿尼芬净、卡泊芬净和米卡芬净对杜伯氏念珠菌临床分离株的体外活性，并在两种系统性感染的小鼠模型中评估了这些药物的疗效。对于体外显示或不显示异常生长的杜伯氏念珠菌菌株引起的实验性播散性感染，三种棘白菌素类药物的治疗效果相似。

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Paradoxical growth of Candida dubliniensis does not preclude in vivo response to echinocandin therapy.杜波依斯念珠菌的反常生长并不排除对棘白菌素类治疗的体内反应。
Antimicrob Agents Chemother. 2009 Dec;53(12):5297-9. doi: 10.1128/AAC.00980-09. Epub 2009 Sep 28.
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Breakthrough Candida dubliniensis fungemia in an acute myeloid leukemia patient during voriconazole therapy successfully treated with caspofungin.一名急性髓系白血病患者在伏立康唑治疗期间发生突破性都柏林念珠菌血症，用卡泊芬净成功治疗。
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In vivo pharmacodynamic target investigation for micafungin against Candida albicans and C. glabrata in a neutropenic murine candidiasis model.在中性粒细胞减少小鼠念珠菌病模型中，米卡芬净对白色念珠菌和光滑念珠菌的体内药效学靶点研究。
Antimicrob Agents Chemother. 2008 Oct;52(10):3497-503. doi: 10.1128/AAC.00478-08. Epub 2008 Jul 14.
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Candida dubliniensis meningitis as delayed sequela of treated C. dubliniensis fungemia.都柏林念珠菌性脑膜炎作为已治疗的都柏林念珠菌血症的迟发性后遗症。
Emerg Infect Dis. 2008 Feb;14(2):327-9. doi: 10.3201/eid1402.070985.
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In vivo pharmacodynamic characterization of anidulafungin in a neutropenic murine candidiasis model.阿尼芬净在中性粒细胞减少小鼠念珠菌病模型中的体内药效学特征
Antimicrob Agents Chemother. 2008 Feb;52(2):539-50. doi: 10.1128/AAC.01061-07. Epub 2007 Dec 10.
5
Paradoxical growth effects of the echinocandins caspofungin and micafungin, but not of anidulafungin, on clinical isolates of Candida albicans and C. dubliniensis.棘白菌素类药物卡泊芬净和米卡芬净（而非阿尼芬净）对白色念珠菌和都柏林念珠菌临床分离株具有矛盾的生长效应。
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Antimicrob Agents Chemother. 2005 Nov;49(11):4757-9. doi: 10.1128/AAC.49.11.4757-4759.2005.
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Azole susceptibility and resistance in Candida dubliniensis.都柏林念珠菌对唑类药物的敏感性和耐药性
Biochem Soc Trans. 2005 Nov;33(Pt 5):1210-4. doi: 10.1042/BST20051210.