杜波依斯念珠菌的反常生长并不排除对棘白菌素类治疗的体内反应。
Paradoxical growth of Candida dubliniensis does not preclude in vivo response to echinocandin therapy.
机构信息
Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain.
出版信息
Antimicrob Agents Chemother. 2009 Dec;53(12):5297-9. doi: 10.1128/AAC.00980-09. Epub 2009 Sep 28.
Abstract
Candida dubliniensis commonly shows paradoxical or trailing growth effects in vitro in the presence of echinocandins. We tested the in vitro activities of anidulafungin, caspofungin, and micafungin against clinical isolates of C. dubliniensis and evaluated the efficacy of these drugs in two murine models of systemic infection. The three echinocandins were similarly effective in the treatment of experimental disseminated infections with C. dubliniensis strains showing or not showing abnormal growth in vitro.
摘要
杜伯氏念珠菌在体外接触棘白菌素类药物时通常表现出反常或拖曳样生长效应。我们检测了棘白菌素类药物中的阿尼芬净、卡泊芬净和米卡芬净对杜伯氏念珠菌临床分离株的体外活性，并在两种系统性感染的小鼠模型中评估了这些药物的疗效。对于体外显示或不显示异常生长的杜伯氏念珠菌菌株引起的实验性播散性感染，三种棘白菌素类药物的治疗效果相似。
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