Department of Medicine D, Meir Medical Center, Kfar-Saba, Israel. Affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Tshernichovsky 59, 44281 Kfar-Saba, Israel.
Rheumatol Int. 2011 Apr;31(4):525-7. doi: 10.1007/s00296-009-1168-0. Epub 2009 Oct 22.
Crohn's disease (CD) is a well defined inflammatory bowel disease. Patients primarily present with abdominal pain and diarrhea, however, extra-intestinal manifestations due to musculoskeletal and cutaneous involvement are seen in a varying range of patients. In this communication we describe a young woman who presented with a severe inflammatory illness that consequently developed into pyoderma gangrenosum, anterior tibialis myositis and arthritis that were all antecedent to the intestinal involvement. The patient favorably responded to infliximab with concomitant azathioprine therapy.
克罗恩病（CD）是一种明确的炎症性肠病。患者主要表现为腹痛和腹泻，但由于肌肉骨骼和皮肤受累，不同程度的患者会出现肠道外表现。在本通讯中，我们描述了一位年轻女性，她表现出严重的炎症性疾病，随后发展为坏疽性脓皮病、胫骨前肌肌炎和关节炎，所有这些都先于肠道受累。该患者对英夫利昔单抗联合硫唑嘌呤治疗有良好反应。
