Int J Hyperthermia. 2009 Nov;25(7):512-6. doi: 10.3109/02656730903183445.
In order to increase the specific power absorption (SAR) in deep seated tumors, the idea was born to use AC magnetic fields in combination with magnetic particles instead of conventional E-field dominant systems. It was found, that nanoscaled particles were superior to micron-sized, multi-domain particles in terms of SAR due to different mechanisms how the field energy is converted into heat. Crucial parameters were identified for the human application of the method, such as the AC magnetic field amplitude and frequency, the nanoparticle composition and size distribution. Based on these physical and chemical relationships, a new thermotherapy method has been developed to heat up deep regional tumors using aqueous dispersions of iron oxide nanoparticles (magnetic fluids). Several clinical studies were initiated using this new heating technology. The results of the most advanced efficacy study for recurrent glioblastoma multiforme patients in combination with conventional radiation therapy are expected at the end of this year, 16 years after publication of this fundamental paper.
为了提高深部肿瘤的比吸收率（SAR），人们想到了一个办法，即在使用磁性粒子的同时采用交流磁场，而不是传统的以电场为主的系统。研究发现，由于磁场能量转化为热能的机制不同，纳米级粒子比微米级多畴粒子在 SAR 方面更具优势。对于该方法的人体应用，已经确定了一些关键参数，如交流磁场的幅度和频率、纳米粒子的组成和粒径分布。基于这些物理和化学关系，开发了一种新的热疗方法，使用氧化铁纳米粒子（磁流体）的水基分散体来加热深部区域性肿瘤。已经使用这项新技术开展了几项临床研究。这项基础研究发表 16 年后，预计今年年底将公布复发性多形性胶质母细胞瘤患者联合常规放疗的最新疗效研究结果。
