孕期与产后1个月及产后1年相比，总IgE及变应原特异性IgE的差异。
Differences in total and allergen specific IgE during pregnancy compared with 1 month and 1 year post partum.
作者信息
Perry Lee M, Ownby Dennis R, Wegienka Ganesa R, Peterson Edward L, Woodcroft Kimberly J, Joseph Christine L, Johnson Christine C
机构信息
Section of Allergy and Immunology, Medical College of Georgia, Augusta, 30912-3790, USA.
出版信息
Ann Allergy Asthma Immunol. 2009 Oct;103(4):342-7. doi: 10.1016/S1081-1206(10)60535-2.
BACKGROUND
Pregnancy alters the function of many body systems, including the immune system. However, little is known regarding the effect of pregnancy on maternal IgE levels or atopy.
OBJECTIVE
To determine whether pregnancy consistently influences serum levels of total or allergen specific IgE.
METHODS
Blood samples were obtained from 764 women during the third trimester of pregnancy and 1 month post partum. A third sample was obtained from 106 of these women 1 year post partum. Samples were analyzed for total and specific IgE to 8 regionally common allergens using a commercially available system. Sensitization was defined as an allergen specific IgE level of 0.35 kU of allergen per liter or higher to any allergen.
RESULTS
Total IgE increased significantly post partum, both at 1 month (40.36 vs 35.37 IU/mL intrapartum; P = .001) and at 1 year (44.97 vs 37.00 IU/mL intrapartum; P = .005). Allergen specific IgE decreased significantly at 1 month for cat, dog, ragweed, timothy grass, and egg (P = .001 to P = .02) but not for dust mite, cockroach, or Alternaria (P = .15 to P = .90). Similar patterns of change in total and specific IgE were seen at 1 year. However, on average, only 3.5% of participants changed sensitization status to the individual allergens studied during the 1 year of observation.
CONCLUSIONS
Compared with intrapartum levels, total IgE levels increased significantly at 1 month and 1 year post partum. Conversely, at the same time points, IgE levels specific for common allergens significantly declined to most but not all allergens. Few women changed their sensitization status over 1 year.
背景
妊娠会改变包括免疫系统在内的许多身体系统的功能。然而，关于妊娠对母体免疫球蛋白E（IgE）水平或特应性的影响知之甚少。
目的
确定妊娠是否持续影响总IgE或变应原特异性IgE的血清水平。
方法
在妊娠晚期和产后1个月从764名女性中采集血样。从其中106名女性产后1年采集第三份样本。使用市售系统分析样本中针对8种区域常见变应原的总IgE和特异性IgE。致敏定义为针对任何变应原的变应原特异性IgE水平达到每升变应原0.35 kU或更高。
结果
产后1个月（产后为40.36 IU/mL，产时为35.37 IU/mL；P = 0.001）和产后1年（产后为44.97 IU/mL，产时为37.00 IU/mL；P = 0.005）总IgE均显著升高。猫、狗、豚草、梯牧草和鸡蛋的变应原特异性IgE在产后1个月显著降低（P = 0.001至P = 0.02），但尘螨、蟑螂或链格孢属真菌的变应原特异性IgE未降低（P = 0.15至P = 0.90）。产后1年总IgE和特异性IgE出现类似的变化模式。然而，在1年的观察期内，平均只有3.5%的参与者对所研究的个体变应原的致敏状态发生了改变。
结论
与产时水平相比，产后1个月和1年总IgE水平显著升高。相反，在相同时间点，大多数但并非所有常见变应原的特异性IgE水平显著下降。很少有女性在1年内改变其致敏状态。
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