Research Centre for Sport and Exercise Performance, University of Wolverhampton, Walsall WS1 3BD, UK.
Br J Sports Med. 2011 Aug;45(10):780-4. doi: 10.1136/bjsm.2009.064089. Epub 2009 Oct 23.
Seventeen male participants (mean (SD) (range): age 33.5 (6.5) years (46-26 years), body mass 80 (9.2) kg (100-63 kg), height 1.81 (0.06) m (1.93- 1.70 m)) ran a marathon to investigate the relationship between systolic function (using cardiac magnetic resonance (CMR)) and diastolic function (using echocardiography) against biomarkers of cardiac damage.
Echocardiographic and cardiac troponin I (cTnI)/N-terminal pro-B-type natriuretic peptide (NTproBNP) data were collected 24 h premarathon, immediately postmarathon and 6 h postmarathon. CMR data were collected 24 h premarathon and at 6 h postmarathon.
Body mass was significantly reduced postmarathon (80 (9.2) vs 78.8 (8.6) kg; p<0.001). There was a significant E/A reduction postmarathon (1.11 (0.34) vs 1.72 (0.44); p<0.05) that remained depressed 6 h postmarathon (1.49 (0.43); p<0.05). CMR demonstrated left ventricular end-diastolic and end-systolic volumes were reduced postmarathon, with a preserved stroke volume. Left ventricular ejection fraction 6 h postmarathon significantly increased (64.4% (4.2%) vs 67.4% (5%); p<0.05). There were significant elevations in cTnI (0.00 vs 0.04 (0.03) μg/l; p<0.05) and NTproBNP (37.4 (24.15) ng/l vs 59.34 (43.3) ng/l; p<0.05) immediately postmarathon. Eight runners had cTnI elevations immediately postmarathon above acute myocardial infarction cutoff levels (≥0.03 μg/l). No correlations between cTnI/NTproBNP and measures of diastolic function (E, A, E/A, isovolumic relaxation time, E deceleration time and E/E') or measures of systolic function (stroke volume or ejection fraction) were observed immediately postmarathon or 6 h postmarathon.
Biomarkers of cardiac damage after prolonged exercise are not associated with either systolic or diastolic functional measures.
17 名男性参与者（平均（标准差）（范围）：年龄 33.5（6.5）岁（46-26 岁），体重 80（9.2）kg（100-63kg），身高 1.81（0.06）m（1.93-1.70m））参加了马拉松比赛，以研究收缩功能（使用心脏磁共振（CMR））和舒张功能（使用超声心动图）与心脏损伤的生物标志物之间的关系。
在马拉松比赛前 24 小时、比赛后立即和比赛后 6 小时收集超声心动图和心脏肌钙蛋白 I（cTnI）/N-末端 pro-B 型利钠肽（NTproBNP）数据。CMR 数据在马拉松比赛前 24 小时和比赛后 6 小时收集。
马拉松赛后体重明显减轻（80（9.2）vs 78.8（8.6）kg；p<0.001）。马拉松赛后 E/A 比显著降低（1.11（0.34）vs 1.72（0.44）；p<0.05），6 小时后仍处于较低水平（1.49（0.43）；p<0.05）。CMR 显示左心室舒张末期和收缩末期容积在马拉松赛后减少，而每搏输出量保持不变。马拉松赛后 6 小时左心室射血分数显著增加（64.4%（4.2%）vs 67.4%（5%）；p<0.05）。cTnI（0.00 与 0.04（0.03）μg/l；p<0.05）和 NTproBNP（37.4（24.15）ng/l 与 59.34（43.3）ng/l；p<0.05）在马拉松赛后立即升高。8 名跑步者在马拉松赛后立即出现 cTnI 升高，超过急性心肌梗死的临界值（≥0.03μg/l）。在马拉松赛后立即或 6 小时后，cTnI/NTproBNP 与舒张功能（E、A、E/A、等容舒张时间、E 减速时间和 E/E'）或收缩功能（每搏输出量或射血分数）的测量值之间均无相关性。
长时间运动后心脏损伤的生物标志物与收缩或舒张功能测量值均无相关性。
