Department of Community Health Sciences, The University of Southern Mississippi, Hattiesburg, MS 39406-0001, USA.
Obes Rev. 2010 Apr;11(4):289-96. doi: 10.1111/j.1467-789X.2009.00677.x. Epub 2009 Oct 27.
The aetiology of obesity is multifactorial. An understanding of the contributions of various causal factors is essential for the proper management of obesity. Although it is primarily thought of as a condition brought on by lifestyle choices, recent evidence shows there is a link between obesity and viral infections. Numerous animal models have documented an increased body weight and a number of physiologic changes, including increased insulin sensitivity, increased glucose uptake and decreased leptin secretion that contribute to an increase in body fat in adenovirus-36 infection. Other viral agents associated with increasing obesity in animals included canine distemper virus, rous-associated virus 7, scrapie, Borna disease virus, SMAM-1 and other adenoviruses. This review attempted to determine if viral infection is a possible cause of obesity. Also, this paper discussed mechanisms by which viruses might produce obesity. Based on the evidence presented in this paper, it can be concluded that a link between obesity and viral infections cannot be ruled out. Further epidemiologic studies are needed to establish a causal link between the two, and determine if these results can be used in future management and prevention of obesity.
肥胖的病因是多因素的。了解各种因果因素的贡献对于肥胖的正确管理至关重要。尽管人们普遍认为肥胖是由生活方式选择引起的，但最近的证据表明，肥胖与病毒感染之间存在关联。许多动物模型记录了体重增加和许多生理变化，包括胰岛素敏感性增加、葡萄糖摄取增加和瘦素分泌减少，这些都导致了腺病毒-36 感染时体脂肪增加。其他与动物肥胖相关的病毒包括犬瘟热病毒、 Rous 相关病毒 7、瘙痒病、Borna 病病毒、SMAM-1 和其他腺病毒。本综述试图确定病毒感染是否是肥胖的一个可能原因。此外，本文还讨论了病毒可能产生肥胖的机制。基于本文提出的证据，可以得出结论，肥胖与病毒感染之间的联系不能排除。需要进一步的流行病学研究来确定两者之间的因果关系，并确定这些结果是否可以用于未来肥胖的管理和预防。
