Johansson M E, Brown M, Hierholzer J C, Thörner A, Ushijima H, Wadell G
Department of Clinical Microbiology, Karolinska Hospital, Stockholm, Sweden.
J Infect Dis. 1991 Feb;163(2):293-9. doi: 10.1093/infdis/163.2.293.
Adenovirus type 31 (Ad31) was isolated from 15 immunocompromised patients in 12 of whom seroconversion was also recorded. Ad31 infection has a substantial clinical relevance since 8 of 10 with lower respiratory tract infection and 4 of 4 with hepatitis died. Therefore, Ad31 isolates from immunocompetent and immunodeficient hosts were compared by restriction endonuclease analysis. Nine genome types were identified among the 79 Ad31 isolates. Pairwise comparison of comigrating restriction fragments indicated that the genome types could be divided into three genomic clusters. Several Ad31 genome types were isolated from immunocompromised patients, but no highly virulent genome type could be found. A genome type was identified in a child with severe combined immunodeficiency who originally was infected with another genome type. This observation is suggested to have evolutionary implications.
31型腺病毒（Ad31）是从15名免疫功能低下的患者中分离出来的，其中12名患者还记录到了血清转化。Ad31感染具有重大的临床意义，因为10例下呼吸道感染患者中有8例死亡，4例肝炎患者全部死亡。因此，通过限制性内切酶分析比较了来自免疫功能正常和免疫功能低下宿主的Ad31分离株。在79株Ad31分离株中鉴定出9种基因组类型。对共迁移的限制性片段进行成对比较表明，基因组类型可分为三个基因组簇。从免疫功能低下的患者中分离出了几种Ad31基因组类型，但未发现高毒力的基因组类型。在一名最初感染另一种基因组类型的严重联合免疫缺陷儿童中鉴定出一种基因组类型。这一观察结果被认为具有进化意义。
