Hodel M, Genné D
Service de médecine interne à La Chaux-de-Fonds, Hôpital neuchâtelois, 2300 La Chaux-de-Fonds.
Rev Med Suisse. 2009 Oct 7;5(220):1979-84.
Antibiotics are widely prescribed in medical practice. Many of them induce or are subject to interactions that may diminish their anti-infectious efficiency or elicit toxic effects. Food intake can influence the effectiveness of an antibiotic. Certain antibiotics can lower the effectiveness of oral contraception. Oral anticoagulation can be influenced to a great extent by antibiotics and controls are necessary. Interactions are also possible via enzymatic induction or inhibition of cytochromes. The use of an interaction list with substrates of cytochromes enables to anticipate. Every new prescription should consider a possible drug or food interaction.
抗生素在医学实践中被广泛使用。其中许多抗生素会引发相互作用或受到相互作用的影响,这些相互作用可能会降低它们的抗感染效果或引发毒性作用。食物摄入会影响抗生素的疗效。某些抗生素会降低口服避孕药的效果。抗生素会在很大程度上影响口服抗凝治疗,因此有必要进行监测。通过细胞色素的酶诱导或抑制也可能发生相互作用。使用包含细胞色素底物的相互作用列表有助于进行预测。每开一张新处方都应考虑可能存在的药物或食物相互作用。