Fischer J E, Hasselgren P O
Department of Surgery, University of Cincinnati, Ohio 45267-0558.
Am J Surg. 1991 Feb;161(2):266-71. doi: 10.1016/0002-9610(91)91143-7.
Sepsis results in muscle catabolism and peripheral release of amino acids with a concomitant uptake of amino acids in liver and acute-phase protein synthesis. In addition, there appears to be a cytokine-induced process that blocks muscle amino acid uptake in sepsis, further diverting amino acids from the periphery to the liver. In this article, evidence that cytokines and glucocorticoids play an important role in the regulation of hepatic and muscle protein metabolism during sepsis is presented.
脓毒症会导致肌肉分解代谢以及外周氨基酸释放，同时肝脏摄取氨基酸并进行急性期蛋白合成。此外，似乎存在一种细胞因子诱导的过程，该过程会在脓毒症时阻断肌肉对氨基酸的摄取，从而进一步将氨基酸从外周转移至肝脏。在本文中，我们展示了细胞因子和糖皮质激素在脓毒症期间肝脏和肌肉蛋白质代谢调节中起重要作用的证据。
