Johnson F Reed, Hauber A Brett, Ozdemir Semra
RTI Health Solutions, RTP, NC 27709-2194, USA.
Value Health. 2009 Jan-Feb;12(1):146-52. doi: 10.1111/j.1524-4733.2008.00391.x.
Conventional standard gamble and time trade-off methods may be inappropriate for eliciting preferences for some health states because both require subjects to make trade-offs between a morbid health state and death. Thus, the objective of this study is to demonstrate the use of conjoint analysis to obtain time trade-off estimates of healthy-year equivalents (HYEs) for clinically relevant durations and severities of acute, self-limiting, or nonfatal conditions such as vasomotor symptoms.
A self-administered, web-enabled, graded-pairs conjoint-analysis survey was developed to elicit women's preferences for reducing the frequency and severity of vasomotor symptoms (daytime hot flushes and night sweats). Observed trade-offs between symptom duration and symptom relief were used to calculate HYEs for different severities and durations of vasomotor symptoms.
A total of 523 women with a mean age of 52 years completed the survey. For these women, an improvement from severe to moderate vasomotor symptoms yields a gain of 4.44 HYEs, and an improvement from moderate to mild vasomotor symptoms over 1 year yields a gain of 4.62 HYEs over a period of 7 years. HYE gains for symptom relief are larger for younger women than for older women.
Conjoint analysis is a feasible method for estimating HYEs for acute, self-limiting, or nonfatal conditions. This approach may provide an alternative utility-elicitation method when conventional standard gamble and time trade-off methods are inappropriate to the decision context.
传统的标准博弈法和时间权衡法可能不适用于引出某些健康状态的偏好，因为这两种方法都要求受试者在病态健康状态和死亡之间进行权衡。因此，本研究的目的是证明联合分析的应用，以获得与临床相关的急性、自限性或非致命性疾病（如血管舒缩症状）的持续时间和严重程度的健康年等效值（HYEs）的时间权衡估计。
开发了一项自我管理的、基于网络的、分级配对联合分析调查，以引出女性对减少血管舒缩症状（白天潮热和盗汗）的频率和严重程度的偏好。观察到的症状持续时间和症状缓解之间的权衡用于计算不同严重程度和持续时间的血管舒缩症状的HYEs。
共有523名平均年龄为52岁的女性完成了调查。对于这些女性，血管舒缩症状从严重改善到中度可获得4.44个HYEs的收益，血管舒缩症状从中度改善到轻度且持续1年，在7年的时间里可获得4.62个HYEs的收益。症状缓解的HYEs收益对年轻女性比对老年女性更大。
联合分析是估计急性、自限性或非致命性疾病的HYEs的一种可行方法。当传统标准博弈法和时间权衡法不适用于决策背景时，这种方法可能提供一种替代的效用引出方法。
