Gloth F M, Tobin J D, Sherman S S, Hollis B W
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
J Am Geriatr Soc. 1991 Feb;39(2):137-41. doi: 10.1111/j.1532-5415.1991.tb01615.x.
A population of sunlight-deprived elderly was studied to determine the daily intake of vitamin D and whether dietary intake was sufficient to maintain a normal vitamin D status. Twenty-two subjects over 65 years old with serum creatinine less than 180 mumols/L and confined indoors for more than 6 months were chosen from the community and a nursing home in Southeast Baltimore. Three-day food records were obtained along with serum levels of 25-hydroxyvitamin D (25-OHD), 1,25-dihydroxyvitamin D (1,25-(OH)2 D), and intact parathyroid hormone (PTH). The mean daily vitamin D intake was over twofold greater than the adult Recommended Daily Allowance (RDA) of 200 IU. The mean 25-OHD level was 40 nmol/L (normal 25-138 nmol/L) with seven patients less than 25 nmol/L. Of these participants with 25-OHD values less than 25 nmol/L, the mean vitamin D intake was 467 IU (range 36-1096 IU). We conclude that the current RDA seems inadequate for many older individuals who do not get sun exposure. This particular population of elderly is at risk to develop vitamin D deficiency and the associated complications.
对一群缺乏阳光照射的老年人进行了研究,以确定维生素D的每日摄入量,以及饮食摄入量是否足以维持正常的维生素D状态。从巴尔的摩东南部的社区和一家养老院中选取了22名65岁以上、血清肌酐低于180μmol/L且在室内居住超过6个月的受试者。收集了他们三天的饮食记录以及血清25-羟基维生素D(25-OHD)、1,25-二羟基维生素D(1,25-(OH)2 D)和完整甲状旁腺激素(PTH)的水平。维生素D的平均每日摄入量比成人推荐每日摄入量(RDA)200 IU高出两倍多。25-OHD的平均水平为40 nmol/L(正常范围为25-138 nmol/L),有7名患者低于25 nmol/L。在这些25-OHD值低于25 nmol/L的参与者中,维生素D的平均摄入量为467 IU(范围为36-1096 IU)。我们得出结论,对于许多没有阳光照射的老年人来说,目前的RDA似乎并不充足。这一特定群体的老年人有患维生素D缺乏症及相关并发症的风险。