Hardwick L L, Jones M R, Brautbar N, Lee D B
Division of Nephrology (111R), Veterans Administration Medical Center, Sepulveda, CA 91343.
J Nutr. 1991 Jan;121(1):13-23. doi: 10.1093/jn/121.1.13.
Magnesium absorption has been studied in both humans and animals under diverse experimental conditions. As a result, the data often appear confusing and conflicting. In this review we attempt to summarize information concerning Mg absorption and, where possible, to reconcile apparently conflicting observations. Most studies suggest that Mg is absorbed predominantly in the distal intestine. At usual Mg intakes, Mg absorption occurs primarily by intercellular diffusional and solvent drag mechanisms. There is evidence for a saturable component of Mg absorption in the small intestine and the descending colon that is important at low dietary Mg intakes. Pharmacological doses of vitamin D increase Mg absorption in both vitamin D-deficient and vitamin D-replete animals. A substantial amount of Mg absorption, however, occurs independent of vitamin D. In addition, vitamin D may reduce Mg retention through increases in urinary Mg excretion. Intestinal interactions between Mg and calcium or phosphate have been demonstrated in both humans and animals. The nature of these interactions cannot be readily explained by data currently available.
在不同的实验条件下，对人类和动物的镁吸收情况都进行了研究。因此，数据常常显得令人困惑且相互矛盾。在本综述中，我们试图总结有关镁吸收的信息，并在可能的情况下协调明显相互矛盾的观察结果。大多数研究表明，镁主要在远端肠道被吸收。在通常的镁摄入量下，镁的吸收主要通过细胞间扩散和溶剂拖曳机制进行。有证据表明，在小肠和降结肠中存在镁吸收的饱和成分，这在低膳食镁摄入量时很重要。药理剂量的维生素D可增加维生素D缺乏和维生素D充足动物的镁吸收。然而，大量的镁吸收是独立于维生素D发生的。此外，维生素D可能通过增加尿镁排泄来减少镁的潴留。在人类和动物中都已证明镁与钙或磷之间存在肠道相互作用。目前可用的数据尚无法轻易解释这些相互作用的性质。
