Navajo Nation Veterinary Program, Navajo Nation, Chinle, AZ, USA.
Vaccine. 2009 Nov 27;27(51):7210-3. doi: 10.1016/j.vaccine.2009.09.026.
Parenteral vaccination campaigns are integral to the elimination of canine rabies. To maximize herd immunity in dogs, immunocontraception provided at the time of rabies vaccination should reduce fecundity and dog abundance. GonaCon has been used successfully as an immunocontraceptive in a variety of mammals, and by inference, the dog would be an ideal candidate for testing. As an initial step in evaluating a combination-vaccination program, we assessed the effects of GonaCon on rabies virus neutralizing antibody production in dogs after administration of a veterinary rabies vaccine. Eighteen feral/free ranging dogs were included in this initial study: six were given GonaCon only, six were given rabies vaccination only, and six received GonaCon and rabies vaccination. Antibody levels were evaluated over 82 days. The use of the immunocontraceptive GonaCon did not affect the ability of dogs to seroconvert in response to the rabies vaccine. Thus, GonaCon provides a potential immunocontraceptive for use in combination with rabies vaccine to increase herd immunity and address dog population over abundance to better manage rabies.
狂犬病的消灭与动物的接种疫苗息息相关。为了使犬群的免疫力最大化，免疫避孕应该在接种狂犬病疫苗时实施，从而降低繁殖率和犬只数量。在多种哺乳动物中， Gonacon 已被成功用作免疫避孕药，并且推断，狗将是测试的理想候选者。作为评估联合疫苗接种计划的初步步骤，我们评估了 Gonacon 在给兽医狂犬病疫苗后对狗的狂犬病病毒中和抗体产生的影响。这项初步研究包括 18 只野生/自由放养的狗：6 只仅接受 Gonacon 治疗，6 只仅接受狂犬病疫苗接种，6 只同时接受 Gonacon 和狂犬病疫苗接种。在 82 天内评估了抗体水平。免疫避孕药 Gonacon 的使用并未影响狗对狂犬病疫苗产生血清转化的能力。因此， Gonacon 为提高群体免疫力和解决犬群过剩问题以更好地管理狂犬病提供了一种潜在的免疫避孕药与狂犬病疫苗联合使用的方法。
