吸烟对暴露于加湿器污染物的工厂工人过敏性疾病发展及特异性免疫反应的影响。
The effect of smoking on the development of allergic disease and specific immunological responses in a factory workforce exposed to humidifier contaminants.
作者信息
Finnegan M J, Little S, Gordon D J, Austwick P K, Tee R D, Nunn A J, Newman-Taylor A J
机构信息
Brompton Hospital, London.
出版信息
Br J Ind Med. 1991 Jan;48(1):30-3. doi: 10.1136/oem.48.1.30.
The effects of smoking on the development of work related asthma and on the production of specific IgE and IgG antibodies to antigen from a contaminated humidifier are described for a sample of 258 workers from a printing factory. Current smoking was associated with low production of IgG antibody but with higher production of IgE antibody. No dose response for either antibody was found when numbers of cigarettes or pack-years smoked were considered. Work related asthma was detected in 12 workers by peak flow recordings. Six were current smokers and one was an ex-smoker. One subject with work related asthma had a high (and one a marginal) concentration of specific IgE to humidifier antigen.
针对一家印刷厂的258名工人样本，描述了吸烟对职业性哮喘发展以及针对受污染加湿器抗原的特异性IgE和IgG抗体产生的影响。当前吸烟与IgG抗体产量低但IgE抗体产量高有关。在考虑吸烟支数或吸烟包年数时，未发现两种抗体的剂量反应。通过峰值流速记录在12名工人中检测到职业性哮喘。其中6人是当前吸烟者，1人是既往吸烟者。一名患有职业性哮喘的受试者对加湿器抗原有高（另一名为临界）浓度的特异性IgE。
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