Department of Paediatrics, BC Children's Hospital and Child & Family Research Institute, University of British Columbia, Vancouver, BC, Canada.
J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S24-32. doi: 10.1016/j.jaci.2009.07.016. Epub 2009 Nov 24.
Recent years have witnessed an explosion of interest in the innate immune system. Questions about how the innate immune system senses infection and empowers a protective immune response are being answered at the molecular level. These basic science discoveries are being translated into a more complete understanding of the central role innate immunity plays in the pathogenesis of many human infectious and inflammatory diseases. It is particularly exciting that we are already seeing a return on these scientific investments with the emergence of novel therapies to harness the power of the innate immune system. In this review we explore the defining characteristics of the innate immune system, and through more detailed examples, we highlight recent breakthroughs that have advanced our understanding of the role of innate immunity in human health and disease.
近年来,人们对先天免疫系统产生了浓厚的兴趣。关于先天免疫系统如何感知感染并激发保护性免疫反应的问题正在分子水平上得到解答。这些基础科学发现正在被转化为对先天免疫在许多人类感染和炎症性疾病发病机制中所起的核心作用的更完整的理解。特别令人兴奋的是,我们已经看到这些科学投资的回报,出现了利用先天免疫系统的力量的新型疗法。在这篇综述中,我们探讨了先天免疫系统的定义特征,并通过更详细的例子,强调了最近的突破,这些突破提高了我们对先天免疫在人类健康和疾病中的作用的理解。