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Tissue engineering: Function follows form.

作者信息

Iatridis James C

出版信息

Nat Mater. 2009 Dec;8(12):923-4. doi: 10.1038/nmat2577.

DOI:10.1038/nmat2577
PMID:19935690
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3004472/
Abstract
摘要

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Tissue engineering: Function follows form.组织工程学：功能随形态而定。
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The intervertebral disc: from pathophysiology to tissue engineering.椎间盘：从病理生理学到组织工程
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Decellularized Scaffolds for Intervertebral Disc Regeneration.去细胞支架在椎间盘再生中的应用。
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Strategies for regeneration of the intervertebral disc.椎间盘再生的策略。
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A phenotypic comparison of proteoglycan production of intervertebral disc cells isolated from rats, rabbits, and bovine tails; which animal model is most suitable to study tissue engineering and biological repair of human disc disorders?比较从大鼠、兔和牛尾分离的椎间盘细胞的蛋白聚糖产生的表型；哪种动物模型最适合研究人类椎间盘疾病的组织工程和生物修复？
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The challenge and advancement of annulus fibrosus tissue engineering.纤维环组织工程的挑战与进展。
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Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):477-482. doi: 10.1073/pnas.1715912115. Epub 2017 Dec 27.
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Gene expression modulation in TGF-β3-mediated rabbit bone marrow stem cells using electrospun scaffolds of various stiffness.使用不同刚度的电纺支架对转化生长因子-β3介导的兔骨髓干细胞进行基因表达调控。
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Regional variations in the cellular, biochemical, and biomechanical characteristics of rabbit annulus fibrosus.兔纤维环细胞、生化及生物力学特性的区域差异。
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Tissue-engineered intervertebral discs produce new matrix, maintain disc height, and restore biomechanical function to the rodent spine.组织工程化的椎间盘可产生新的基质，维持椎间盘高度，并恢复啮齿动物脊柱的生物力学功能。
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本文引用的文献

1
Localized Intervertebral Disc Injury Leads to Organ Level Changes in Structure, Cellularity, and Biosynthesis.局部椎间盘损伤导致器官水平的结构、细胞组成和生物合成变化。
Cell Mol Bioeng. 2009 Sep 1;2(3):437-447. doi: 10.1007/s12195-009-0072-8.
2
Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus.纳米纤维生物层压板复制了纤维环的形态和功能。
Nat Mater. 2009 Dec;8(12):986-92. doi: 10.1038/nmat2558. Epub 2009 Oct 25.
3
Measurement of local strains in intervertebral disc anulus fibrosus tissue under dynamic shear: contributions of matrix fiber orientation and elastin content.动态剪切下纤维环组织中局部应变的测量：基质纤维方向和弹性蛋白含量的贡献。
J Biomech. 2009 Oct 16;42(14):2279-85. doi: 10.1016/j.jbiomech.2009.06.047. Epub 2009 Aug 6.
4
Differential phenotype of intervertebral disc cells: microarray and immunohistochemical analysis of canine nucleus pulposus and anulus fibrosus.椎间盘细胞的差异表型：犬髓核和纤维环的微阵列及免疫组织化学分析
Spine (Phila Pa 1976). 2009 Jun 15;34(14):1448-56. doi: 10.1097/BRS.0b013e3181a55705.
5
Tissue engineering and the intervertebral disc: the challenges.组织工程与椎间盘：挑战
Eur Spine J. 2008 Dec;17 Suppl 4(Suppl 4):480-91. doi: 10.1007/s00586-008-0746-2. Epub 2008 Nov 13.
6
Feasibility of a stem cell therapy for intervertebral disc degeneration.一种用于椎间盘退变的干细胞疗法的可行性。
Spine J. 2008 Nov-Dec;8(6):888-96. doi: 10.1016/j.spinee.2007.09.011. Epub 2007 Dec 21.
7
Intervertebral disc transplantation in the treatment of degenerative spine disease: a preliminary study.椎间盘移植治疗退行性脊柱疾病：一项初步研究。
Lancet. 2007 Mar 24;369(9566):993-9. doi: 10.1016/S0140-6736(07)60496-6.
8
Mechanobiology of the intervertebral disc and relevance to disc degeneration.椎间盘的力学生物学及其与椎间盘退变的相关性。
J Bone Joint Surg Am. 2006 Apr;88 Suppl 2:52-7. doi: 10.2106/JBJS.F.00001.
9
Tissue engineering: a live disc.组织工程：一张活盘。
Nat Mater. 2005 Dec;4(12):881-2. doi: 10.1038/nmat1540.
10
Animal models of intervertebral disc degeneration: lessons learned.椎间盘退变的动物模型：经验教训
Spine (Phila Pa 1976). 2004 Dec 1;29(23):2742-50. doi: 10.1097/01.brs.0000146498.04628.f9.