Dau Birgitt, Holodniy Mark
VA Palo Alto Health Care System and Division of Infectious Diseases and Geographic Medicine, Stanford University, Palo Alto, CA, USA.
Curr Cardiol Rev. 2008 Aug;4(3):203-18. doi: 10.2174/157340308785160589.
Over 30 million people are currently living with human immunodeficiency virus (HIV) infection, and over 2 million new infections occur per year. HIV has been found to directly affect vascular biology resulting in an increased risk of cardiovascular disease compared to uninfected persons. Although HIV infection can now be treated effectively with combination antiretroviral medications, significant toxicities such as hyperlipidemia, diabetes, and excess cardiovascular co-morbidity; as well as the potential for significant drug-drug interactions between HIV and cardiovascular medications, present new challenges for the management of persons infected with HIV. We first review basic principles of HIV pathogenesis and treatment and then discuss relevant clinical management strategies that will be useful for cardiologists who might be involved in the care of HIV infected patients.
目前有超过3000万人感染了人类免疫缺陷病毒（HIV），并且每年有超过200万新发感染病例。与未感染者相比，已发现HIV会直接影响血管生物学，导致心血管疾病风险增加。尽管现在可以通过联合抗逆转录病毒药物有效治疗HIV感染，但存在诸如高脂血症、糖尿病和过多心血管合并症等严重毒性；以及HIV与心血管药物之间发生显著药物相互作用的可能性，这给HIV感染者的管理带来了新的挑战。我们首先回顾HIV发病机制和治疗的基本原则，然后讨论相关的临床管理策略，这些策略对可能参与HIV感染患者护理的心脏病专家会有所帮助。
