Ghosh A, Liu T, Khoury M J, Valdez R
Biomedical Research Laboratory, Department of Anthropology, Visva Bharati University, Sriniketan, India.
Public Health Genomics. 2010;13(6):353-9. doi: 10.1159/000262330. Epub 2009 Nov 26.
BACKGROUND/AIMS: Type 2 diabetes and cardiovascular disease share risk factors. The influence of family history of diabetes on the odds of having metabolic syndrome has not been estimated for the U.S. population. Our objective was to quantify this association in a national sample of U.S. adults without diabetes.
The sample included 4,937 individuals from the National Health and Nutrition Examination Survey (NHANES) (1999-2004). Familial risk of diabetes was classified in 3 strata according to the combination of relatives affected. Metabolic syndrome was defined according to guidelines issued by 4 groups or organizations. The prevalence and odds of this syndrome were compared among familial risk strata after controlling for relevant risk factors.
Overall, depending on the definition and after controlling for key variables, people with a moderate familial risk of diabetes, and people with a high familial risk of diabetes were between 1.4 and 1.6, and 1.6 and 1.8 times as likely, respectively, to have metabolic syndrome compared to people with average familial risk.
In a nationally representative sample of U.S. adults without diabetes, family history of diabetes shows a significant, independent association with metabolic syndrome and its traits. This association supports the idea that shared genes and environment contribute to the expression of complex traits such as diabetes and the metabolic syndrome.
背景/目的：2型糖尿病和心血管疾病有共同的危险因素。尚未对美国人群中糖尿病家族史对患代谢综合征几率的影响进行评估。我们的目标是在无糖尿病的美国成年人全国样本中量化这种关联。
样本包括来自国家健康和营养检查调查（NHANES）（1999 - 2004年）的4937名个体。根据受影响亲属的组合，将糖尿病家族风险分为3个层次。代谢综合征根据4个团体或组织发布的指南进行定义。在控制相关危险因素后，比较家族风险层次之间该综合征的患病率和几率。
总体而言，根据定义并在控制关键变量后，与家族风险平均的人相比，糖尿病家族风险中等的人和糖尿病家族风险高的人患代谢综合征的可能性分别为1.4至1.6倍和1.6至1.8倍。
在具有全国代表性的无糖尿病美国成年人样本中，糖尿病家族史与代谢综合征及其特征存在显著的独立关联。这种关联支持了共享基因和环境促成糖尿病和代谢综合征等复杂特征表达的观点。
