Regional Cystic Fibrosis Unit, St James University Hospital, Beckett Street, Leeds, United Kingdom.
J Cyst Fibros. 2010 Jan;9(1):64-8. doi: 10.1016/j.jcf.2009.11.004. Epub 2009 Nov 27.
Pseudomonas aeruginosa is a common and important pathogen in people with cystic fibrosis (CF). Recently epidemic strains of P. aeruginosa associated with increased morbidity, have been identified. The method of transmission is not clear, but there is evidence of a potential airborne route. The aim of this study was to determine whether different strains of P. aeruginosa isolated from people with CF were able to survive within artificially generated aerosols in an aerobiological chamber. Viable P. aeruginosa could still be detected up to 45min after halting generation of the aerosols. All of the strains of P. aeruginosa expressing a non-mucoid phenotype isolated from people with CF had a reduced ability to survive within aerosols compared to an environmental strain. Expression of a mucoid phenotype by the strains of P. aeruginosa isolated from people with CF promoted survival in the aerosol model compared to strains expressing a non-mucoid phenotype.
铜绿假单胞菌是囊性纤维化（CF）患者中常见且重要的病原体。最近发现了与发病率增加相关的流行株铜绿假单胞菌。传播途径尚不清楚，但有潜在空气传播途径的证据。本研究旨在确定从 CF 患者中分离出的不同铜绿假单胞菌菌株是否能够在空气生物学室中的人工气溶胶中存活。气溶胶停止产生后长达 45 分钟仍可检测到存活的铜绿假单胞菌。与环境菌株相比，所有从 CF 患者中分离出的表达非粘液表型的铜绿假单胞菌菌株在气溶胶中的存活能力均降低。与表达非粘液表型的菌株相比，CF 患者分离株中表达粘液表型的铜绿假单胞菌菌株在气溶胶模型中更能存活。
