人胃和大肠腺癌中的鸟氨酸脱羧酶活性及多胺含量
Ornithine decarboxylase activity and polyamine content in adenocarcinomas of human stomach and large intestine.
作者信息
Berdinskikh N K, Ignatenko N A, Zaletok S P, Ganina K P, Chorniy V A
机构信息
Department of Tumor Biochemistry, R.E. Kavetsky Institute for Oncological Problems, Academy of Sciences, Ukrainian SSR, Kiev.
出版信息
Int J Cancer. 1991 Feb 20;47(4):496-8. doi: 10.1002/ijc.2910470404.
Ornithine decarboxylase (ODC) activity and differential polyamine composition have been studied in macroscopically normal mucosa, adjacent mucosa, and neoplastic tissue of 95 patients with adenocarcinomas of stomach and large intestine. In tumors, we found increased ODC activity and polyamine content as compared with surrounding mucosa. ODC activity in macroscopically normal tissue of patients with tumors of stomach and large intestine increased as the disease progressed. An inverse relationship was observed between ODC activity in adenocarcinomas and differentiation.
对95例胃癌和大肠癌患者的大体正常黏膜、相邻黏膜及肿瘤组织中的鸟氨酸脱羧酶（ODC）活性和多胺组成差异进行了研究。在肿瘤组织中，我们发现与周围黏膜相比，ODC活性和多胺含量增加。胃癌和大肠癌患者大体正常组织中的ODC活性随疾病进展而升高。腺癌中的ODC活性与分化之间呈负相关。
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