谷氨酰胺合成酶 I 的非编码 RNA 调节变铅青链霉菌 A3(2)中的抗生素产生。
Noncoding RNA of glutamine synthetase I modulates antibiotic production in Streptomyces coelicolor A3(2).
机构信息
Department of Microbial Physiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands.
出版信息
J Bacteriol. 2010 Feb;192(4):1160-4. doi: 10.1128/JB.01374-09. Epub 2009 Dec 4.
Abstract
Overexpression of antisense chromosomal cis-encoded noncoding RNAss (ncRNAs) in glutamine synthetase I resulted in a decrease in growth, protein synthesis, and antibiotic production in Streptomyces coelicolor. In addition, we predicted 3,597 cis-encoded ncRNAs and validated 13 of them experimentally, including several ncRNAs that are differentially expressed in bacterial hormone-defective mutants.
摘要
反义染色体顺式编码非编码 RNA（ncRNAs）在谷氨酰胺合成酶 I 中的过表达导致链霉菌生长、蛋白质合成和抗生素产量的下降。此外，我们预测了 3597 个顺式编码 ncRNAs，并通过实验验证了其中的 13 个，包括一些在细菌激素缺陷突变体中差异表达的 ncRNAs。
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