Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
J Epidemiol. 2010;20(1):62-9. doi: 10.2188/jea.je20081041. Epub 2009 Dec 5.
Metabolic syndrome increases the morbidity and mortality of cardiovascular diseases. However, few studies have examined the association between the incidence of stroke and metabolic syndrome, as defined by Japanese criteria. The aim of this study was to identify the association between stroke and metabolic syndrome, as defined by criteria used in Japan.
A total of 2205 subjects (920 men and 1285 women) were examined between 1992 and 1995 as part of the Jichi Medical School Cohort Study. Metabolic syndrome was defined using the Japanese criteria. Medical records, computed tomography, and magnetic resonance imaging were used to diagnose stroke. The Cox proportional-hazards model was used to analyze the association between metabolic syndrome and incident stroke.
The prevalence of metabolic syndrome at baseline was 9.0% in men and 1.7% in women. There were 96 incident strokes during an 11.2-year follow-up period, 14 of which occurred in subjects with metabolic syndrome. Among subjects with metabolic syndrome, the age-adjusted hazard ratio (95% confidence interval) for stroke was 1.93 (0.94-3.96) in men and 6.85 (2.68-17.47) in women. After adjusting for age, smoking status, and alcohol drinking status, the hazard ratio was 1.89 (0.88-4.08) in men and 7.24 (2.82-18.58) in women. Age-adjusted hazard ratios associated with having 2 or more components of metabolic syndrome, with and without central obesity, were 2.93 (1.21-7.08) and 3.20 (1.23-8.31) in men and 1.75 (0.69-4.44) and 8.64 (2.82-28.03) in women, respectively.
The presence of metabolic syndrome, as defined by Japanese criteria, increases the risk of stroke; this effect was highly significant among women.
代谢综合征会增加心血管疾病的发病率和死亡率。然而，很少有研究检查过日本标准定义的代谢综合征与中风发病率之间的关系。本研究旨在确定日本标准定义的代谢综合征与中风之间的关系。
共有 2205 名受试者（920 名男性和 1285 名女性）于 1992 年至 1995 年期间参加了吉医科大学队列研究。使用日本标准定义代谢综合征。使用病历、计算机断层扫描和磁共振成像来诊断中风。使用 Cox 比例风险模型分析代谢综合征与中风发病之间的关系。
基线时男性代谢综合征的患病率为 9.0%，女性为 1.7%。在 11.2 年的随访期间发生了 96 例中风事件，其中 14 例发生在代谢综合征患者中。在患有代谢综合征的患者中，年龄调整后的中风风险比（95%置信区间）为男性 1.93（0.94-3.96），女性 6.85（2.68-17.47）。在调整年龄、吸烟状况和饮酒状况后，男性的风险比为 1.89（0.88-4.08），女性为 7.24（2.82-18.58）。患有 2 个或更多代谢综合征成分、伴或不伴中心性肥胖的男性年龄调整风险比分别为 2.93（1.21-7.08）和 3.20（1.23-8.31），女性分别为 1.75（0.69-4.44）和 8.64（2.82-28.03）。
日本标准定义的代谢综合征的存在会增加中风的风险；这一效应在女性中尤为显著。
